Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders (S.X., X.J.), Capital Medical University, Beijing, China.
China-America Institute of Neuroscience, Xuanwu Hospital (S.X., J.G., J.H., X.C., Y.X., W.H., D.W., X.J.), Capital Medical University, Beijing, China.
Stroke. 2024 Sep;55(9):2385-2396. doi: 10.1161/STROKEAHA.124.046684. Epub 2024 Jul 16.
Circadian rhythm is a master process observed in nearly every type of cell throughout the body, and it macroscopically regulates daily physiology. Recent clinical trials have revealed the effects of circadian variation on the incidence, pathophysiological processes, and prognosis of acute ischemic stroke. Furthermore, core clock genes, the cell-autonomous pacemakers of the circadian rhythm, affect the neurovascular unit-composing cells in a nonparallel manner after the same pathophysiological processes of ischemia/reperfusion. In this review, we discuss the influence of circadian rhythms and clock genes on each type of neurovascular unit cell in the pathophysiological processes of acute ischemic stroke.
昼夜节律是一种在体内几乎每种类型的细胞中都观察到的主控过程，它宏观上调节着日常的生理机能。最近的临床试验揭示了昼夜节律变化对急性缺血性脑卒中发病、病理生理过程和预后的影响。此外，核心时钟基因是昼夜节律的细胞自主起搏器，在经历相同的缺血/再灌注病理生理过程后，以非平行的方式影响组成神经血管单元的细胞。在这篇综述中，我们讨论了昼夜节律和时钟基因对急性缺血性脑卒中病理生理过程中每种神经血管单元细胞的影响。
