The Key Laboratory of Medical Electrophysiology, Ministry of Education and Medical Electrophysiological Key Lab of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China.
Microcirculation. 2024 Aug;31(6):e12874. doi: 10.1111/micc.12874. Epub 2024 Jul 16.
Shock is characterized with vascular hyporesponsiveness to vasoconstrictors, thereby to cause refractory hypotension, insufficient tissue perfusion, and multiple organ dysfunction. The vascular hyporeactivity persisted even though norepinephrine and fluid resuscitation were administrated, it is of critical importance to find new potential target. Ion channels are crucial in the regulation of cell membrane potential and affect vasoconstriction and vasodilation. It has been demonstrated that many types of ion channels including K channels, Ca permeable channels, and Na channels exist in vascular smooth muscle cells and endothelial cells, contributing to the regulation of vascular homeostasis and vasomotor function. An increasing number of studies suggested that the structural and functional alterations of ion channels located in arteries contribute to vascular hyporesponsiveness during shock, but the underlying mechanisms remained to be fully clarified. Therefore, the expression and functional changes in ion channels in arteries associated with shock are reviewed, to pave the way for further exploring the potential of ion channel-targeted compounds in treating refractory hypotension in shock.
休克的特征为血管对血管收缩剂反应低下，从而导致难治性低血压、组织灌注不足和多器官功能障碍。即使给予去甲肾上腺素和液体复苏，血管低反应性仍然存在，因此寻找新的潜在靶点至关重要。离子通道在调节细胞膜电位方面起着至关重要的作用，并影响血管收缩和舒张。已经证明，许多类型的离子通道，包括 K 通道、Ca 通透性通道和 Na 通道，存在于血管平滑肌细胞和内皮细胞中，有助于调节血管内稳态和血管运动功能。越来越多的研究表明，位于动脉中的离子通道的结构和功能改变导致休克期间的血管低反应性，但潜在机制仍未完全阐明。因此，本文综述了与休克相关的动脉中离子通道的表达和功能变化，为进一步探索靶向离子通道化合物治疗休克难治性低血压的潜力铺平了道路。
