College of Materials Science and Engineering, Qingdao University of Science and Technology (QUST), 53 Zhengzhou Rd., Shibei District, Qingdao 266042, P. R. China.
Department of Respiratory and Critical Care Medicine, Qingdao Eighth People's Hospital, Qingdao 266121, China.
Nanoscale. 2024 Aug 7;16(30):14310-14318. doi: 10.1039/d4nr01769b.
Designing antibacterial agents with rapid bacterial eradication performance is paramount for the treatment of bacteria-infected wounds. Metal nanoclusters (NCs) with aggregation-induced emission (AIE) have been considered as novel photodynamic antibacterial agents without drug resistance, but they suffer from poor photostability and low charge carrier separation efficiency. Herein, we report the design of a photodynamic antibacterial agent by encapsulating AIE-type AgAu NCs (AgAu NCs) into a zeolitic Zn(2-methylimidazole) framework (ZIF-8). The encapsulation of AIE-type AgAu NCs into porous ZIF-8 could not only enhance the photostability of AgAu NCs by inhibiting their aggregation but also promote the separation of photoinduced charge carriers, resulting in the rapid generation of destructive reactive oxygen species (ROS) for bacterial killing under visible-light irradiation. Consequently, the as-designed photodynamic AgAu NCs@ZIF-8 antibacterial agent could rapidly eliminate 97.7% of () and 91.6% of () within 5 min under visible light irradiation. Furthermore, experimental results have highlighted the synergistic effect created by AIE-type AgAu NCs and ZIF-8, enabling AgAu NCs@ZIF-8 to effectively eradicate bacteria in infected areas, reduce inflammation, and promote the generation of blood vessels, epithelial tissue, and collagen. This synergistic effect promoted the healing of -infected wound, with nearly 100% of wound recovery within 11 days. This work may be interesting because it sheds light on the design of metal NC-based photodynamic nanomedicine for bacteria-infected disease treatment.
设计具有快速杀菌性能的抗菌剂对于治疗细菌感染的伤口至关重要。具有聚集诱导发光（AIE）的金属纳米团簇（NCs）被认为是一种新型的无耐药性光动力抗菌剂，但它们存在光稳定性差和载流子分离效率低的问题。在此，我们报告了一种光动力抗菌剂的设计，即将 AIE 型 AgAu NCs（AgAu NCs）封装到沸石咪唑酯骨架（ZIF-8）中。将 AIE 型 AgAu NCs 封装到多孔 ZIF-8 中不仅可以通过抑制聚集来增强 AgAu NCs 的光稳定性，还可以促进光生载流子的分离，从而在可见光照射下快速产生破坏性的活性氧（ROS）以杀死细菌。因此，所设计的光动力 AgAu NCs@ZIF-8 抗菌剂在可见光照射下 5 分钟内可快速消除 97.7%的 和 91.6%的 。此外，实验结果突出了 AIE 型 AgAu NCs 和 ZIF-8 之间的协同作用，使 AgAu NCs@ZIF-8 能够有效清除感染部位的细菌，减轻炎症，并促进血管、上皮组织和胶原蛋白的生成。这种协同作用促进了感染伤口的愈合，在 11 天内几乎实现了 100%的伤口恢复。这项工作可能很有趣，因为它为基于金属 NC 的光动力纳米医学治疗细菌感染疾病的设计提供了新的思路。
