Chitkara University School of Pharmacy, Chitkara University, Baddi, Himachal Pradesh, India.
Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India.
Inflammopharmacology. 2024 Oct;32(5):3057-3077. doi: 10.1007/s10787-024-01517-9. Epub 2024 Jul 16.
Bufadienolides, specifically bufalin, have garnered attention for their potential therapeutic application in modulating inflammatory pathways. Bufalin is derived from toad venom and exhibits promising anti-inflammatory properties. Its anti-inflammatory effects have been demonstrated by influencing crucial signaling pathways like NF-B, MAPK, and JAK-STAT, resulting in the inhibition of pro-inflammatory substances like cytokines, chemokines, and adhesion molecules. Bufalin blocks inflammasome activation and reduces oxidative stress, hence increasing its anti-inflammatory properties. Bufalin has shown effectiveness in reducing inflammation-related diseases such as cancer, cardiovascular problems, and autoimmune ailments in preclinical investigations. Furthermore, producing new approaches of medication delivery and combining therapies with bufalin shows potential for improving its effectiveness and reducing adverse effects. This review explores the pharmacological effects and mechanistic approaches of bufalin as an anti-inflammatory agent, which further highlights its potential for therapy and offers the basis for further study on its therapeutic application in inflammation-related disorders.
蟾毒配基，特别是蟾毒它灵，因其在调节炎症途径方面的潜在治疗应用而受到关注。蟾毒它灵来源于蟾蜍毒液，具有有前景的抗炎特性。其抗炎作用通过影响关键信号通路，如 NF-B、MAPK 和 JAK-STAT，抑制细胞因子、趋化因子和粘附分子等促炎物质来实现。蟾毒它灵可阻断炎症小体的激活并减少氧化应激，从而增强其抗炎特性。在临床前研究中，蟾毒它灵已被证明可有效减轻与炎症相关的疾病，如癌症、心血管问题和自身免疫性疾病。此外，开发新的药物输送方法并结合疗法使用蟾毒它灵，有望提高其疗效并减少不良反应。本综述探讨了蟾毒它灵作为抗炎剂的药理学作用和机制方法，进一步强调了其在治疗中的潜力，并为其在炎症相关疾病中的治疗应用提供了进一步研究的基础。
