鼻内M2SR（M2缺陷型单复制）流感疫苗可诱导成人产生广泛反应性黏膜抗体。 - Suppr

Intranasal M2SR (M2-Deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults.

作者信息

Hill-Batorski Lindsay, Weiner Joshua A, Ackerman Margaret E, Hatta Yasuko, Hoft Daniel F, Herber Renee, Moser Michael J, Bilsel Pamuk

机构信息

FluGen, Inc, Madison, Wisconsin.

Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire.

出版信息

J Infect Dis. 2025 Feb 4;231(1):214-218. doi: 10.1093/infdis/jiae361.

DOI:10.1093/infdis/jiae361

PMID:39012796

Abstract

摘要

相似文献

Intranasal M2SR (M2-Deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults.鼻内M2SR（M2缺陷型单复制）流感疫苗可诱导成人产生广泛反应性黏膜抗体。

J Infect Dis. 2025 Feb 4;231(1):214-218. doi: 10.1093/infdis/jiae361.

Intranasal M2SR (M2-Deficient Single Replication) H3N2 Influenza Vaccine Provides Enhanced Mucosal and Serum Antibodies in Adults.鼻腔内接种 M2SR（M2 缺陷型单复制）H3N2 流感疫苗可增强成年人的黏膜和血清抗体。

J Infect Dis. 2022 Dec 28;227(1):103-112. doi: 10.1093/infdis/jiac433.

Safety and immunogenicity of the intranasal H3N2 M2-deficient single-replication influenza vaccine alone or coadministered with an inactivated influenza vaccine (Fluzone High-Dose Quadrivalent) in adults aged 65-85 years in the USA: a multicentre, randomised, double-blind, double-dummy, phase 1b trial.美国65 - 85岁成年人中，鼻内接种H3N2 M2缺陷型单复制流感疫苗单独使用或与灭活流感疫苗（Fluzone高剂量四价疫苗）联合使用的安全性和免疫原性：一项多中心、随机、双盲、双模拟1b期试验。

Lancet Infect Dis. 2024 Oct;24(10):1118-1129. doi: 10.1016/S1473-3099(24)00351-7. Epub 2024 Jul 11.

Longevity and Mechanism of Heterosubtypic Protection Induced by M2SR (M2-Deficient Single-Replication) Live Influenza Virus Vaccine in Mice.M2SR（M2缺陷单复制）活流感病毒疫苗在小鼠中诱导的异亚型保护的寿命及机制

Vaccines (Basel). 2022 Dec 13;10(12):2131. doi: 10.3390/vaccines10122131.

Intranasal Single-Replication Influenza Vector Induces Cross-Reactive Serum and Mucosal Antibodies against SARS-CoV-2 Variants.鼻内单复制流感载体诱导针对SARS-CoV-2变体的交叉反应性血清和粘膜抗体。

Vaccines (Basel). 2023 Jun 5;11(6):1063. doi: 10.3390/vaccines11061063.

Safety and Immunogenicity of M2-Deficient, Single Replication, Live Influenza Vaccine (M2SR) in Adults.成人中M2缺陷型单复制活流感疫苗（M2SR）的安全性和免疫原性

Vaccines (Basel). 2021 Nov 24;9(12):1388. doi: 10.3390/vaccines9121388.

Novel influenza vaccine M2SR protects against drifted H1N1 and H3N2 influenza virus challenge in ferrets with pre-existing immunity.新型流感疫苗 M2SR 可预防具有预先存在免疫的雪貂感染 drifted H1N1 和 H3N2 流感病毒。

Vaccine. 2018 Aug 9;36(33):5097-5103. doi: 10.1016/j.vaccine.2018.06.053. Epub 2018 Jul 13.

Intranasal M2SR and BM2SR Vaccine Viruses Do Not Shed or Transmit in Ferrets.经鼻内接种的M2SR和BM2SR疫苗病毒不会在雪貂体内脱落或传播。

Vaccines (Basel). 2024 Oct 29;12(11):1228. doi: 10.3390/vaccines12111228.

M2-Deficient Single-Replication Influenza Vaccine-Induced Immune Responses Associated With Protection Against Human Challenge With Highly Drifted H3N2 Influenza Strain.M2 缺陷型单复制流感疫苗诱导的免疫应答与对高度漂移 H3N2 流感株人体挑战的保护作用相关。

J Infect Dis. 2022 Aug 12;226(1):83-90. doi: 10.1093/infdis/jiab374.

Quadrivalent Formulation of Intranasal Influenza Vaccine M2SR (M2-Deficient Single Replication) Protects against Drifted Influenza A and B Virus Challenge.鼻内流感疫苗M2SR（M2缺陷单复制）四价制剂可抵御甲型和乙型流感病毒变异株攻击。

Vaccines (Basel). 2023 Apr 4;11(4):798. doi: 10.3390/vaccines11040798.

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Intranasal M2SR (M2-Deficient Single Replication) Influenza Vaccine Induces Broadly Reactive Mucosal Antibody Production in Adults.

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