Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB); Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS); CIBERSAM, ISCIII, Barcelona, Spain; BIOARABA, Department Psychiatry. Hospital Universitario de Alava. CIBERSAM. University of the Basque Country, Vitoria, Spain.
Bipolar and Depressive Disorders Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB); Fundació Clínic-Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS); CIBERSAM, ISCIII, Barcelona, Spain; Barcelona Clinic Schizophrenia Unit, Hospital Clínic de Barcelona; Departament de Medicina, Institut de Neurociències (UBNeuro), Universitat de Barcelona (UB); Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS); CIBERSAM, ISCIII, Barcelona, Spain.
Eur Neuropsychopharmacol. 2024 Aug;85:66-77. doi: 10.1016/j.euroneuro.2024.05.006. Epub 2024 Jul 15.
Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles in EI and NC performance in FEP. 98 adult FEP patients and 128 healthy controls (HCs) were tested on clinical, functional, EI, and NC variables at baseline and two-year follow-up (FUP). A repeated-measures ANOVA compared the effects of group (patients and HCs) and time on EI. Significant EI improvements were observed in both groups. Four groups were created based on NC and EI performance at baseline and FUP in patients: impairment in NC and EI, impairment in NC only, impairment in EI only, and no impairment. At FUP, patients impaired in NC and EI showed less cognitive reserve (CR), greater negative and positive symptoms, and poorer functional outcomes. At FUP, three group trajectories were identified: (I) maintain dual impairment (II) maintain no impairment or improve, (III) maintain sole impairment or worsen. The maintain dual impairment group had the lowest levels of CR. EI and NC impairments progress differently in FEP. Greater CR may protect against comorbid EI/NC impairment. Identifying these patient characteristics could contribute to the development of personalised interventions.
情绪智力 (EI) 和神经认知 (NC) 损伤在首发精神病 (FEP) 中很常见，但它们随时间的演变仍不清楚。本研究确定了 FEP 中 EI 和 NC 表现的患者特征。98 名成年 FEP 患者和 128 名健康对照 (HC) 在基线和两年随访 (FUP) 时接受了临床、功能、EI 和 NC 变量的测试。重复测量方差分析比较了组 (患者和 HC) 和时间对 EI 的影响。两组均观察到 EI 显著改善。根据患者基线和 FUP 的 NC 和 EI 表现，创建了四个组：NC 和 EI 受损、仅 NC 受损、仅 EI 受损和无受损。在 FUP 时，NC 和 EI 受损的患者表现出较少的认知储备 (CR)、更多的正负症状和较差的功能结果。在 FUP 时，确定了三种组轨迹：(I) 维持双重损伤 (II) 维持无损伤或改善，(III) 维持单一损伤或恶化。维持双重损伤组的 CR 水平最低。EI 和 NC 损伤在 FEP 中进展不同。更高的 CR 可能有助于预防并发 EI/NC 损伤。识别这些患者特征可能有助于制定个性化干预措施。
