Physical Performance and Telomere Length in Older Adults.

BACKGROUND

The aging population prompts studying risk factors and markers to predict healthy aging. Telomere length is a promising candidate for assessing various age-related traits.

AIM OF THE STUDY

To investigate the association between physical performance and telomere length.

METHODS

We enrolled 323 older Mexican adults from the "Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults" affiliated with the Instituto Mexicano del Seguro Social and assessed their physical performance using the Short Physical Performance Battery, dividing participants into low (≤7) and high (>7) groups. Absolute telomere length was determined by qPCR, and individuals were classified into short (≤4.22 kb) and long (>4.22 kb) groups. We calculated the mean and adjusted mean, considering sex and age, among others, with 95% CI. We estimated the effect size between physical performance and telomere length using Cohen's d for unequal group sizes and calculated the odds ratio for physical performance based on telomere length.

RESULTS

Participants with low physical performance had significantly shorter telomeres (mean 4.4 kb, adjusted mean 4.0 kb, p <0.001), while those with high physical performance exhibited longer telomeres (mean 5.7 kb, adjusted mean 5.3 kb, p <0.001), with a medium-to-high telomere length effect size (d = 0.762). The odds of low physical activity increased 3.6-fold per kb of telomere attrition (adjOR 3.3, p <0.001).

CONCLUSION

Decreased physical function is associated with shorter telomere length. Absolute telomere length presents a promising biomarker for distinguishing between healthy and unhealthy aging, warranting further investigation.