透析后疲劳可预测慢性血液透析患者的全因死亡率。
Post-dialysis fatigue predicts all-cause mortality in patients on chronic hemodialysis.
作者信息
Watanabe Guy, Tanaka Kenichi, Saito Hirotaka, Kimura Hiroshi, Tani Yoshihiro, Asai Jun, Suzuki Hodaka, Sato Keiji, Nakayama Masaaki, Kazama Junichiro James
机构信息
Department of Nephrology and Hypertension, Fukushima Medical University, Fukushima, Japan.
Division of Advanced Community Based Care for Lifestyle Related Diseases, Fukushima Medical University, Fukushima, Japan.
出版信息
Ther Apher Dial. 2025 Feb;29(1):12-22. doi: 10.1111/1744-9987.14186. Epub 2024 Jul 16.
INTRODUCTION
Fatigue is reportedly associated with a poor prognosis in dialysis patients. The aim of the present study was to investigate whether fatigue on dialysis days or non-dialysis days is associated with mortality in patients on chronic hemodialysis.
METHODS
This was a prospective study of 134 hemodialysis patients. The level of fatigue was evaluated using a visual analog scale (VAS). The association between high fatigue evaluated by the highest quartile of the VAS value and all-cause death was investigated.
RESULTS
The fatigue scale score was significantly higher on dialysis than on non-dialysis days. During the follow-up period (median 6.8 years), 42 patients died. Patients with high post-dialysis fatigue in the higher quartiles died more frequently compared to those with in the lower quartiles (p = 0.012). Multivariate Cox regression analysis showed that high post-dialysis fatigue was an independent predictor of all-cause death (adjusted hazard ratio 2.12, 95% confidence interval 1.10-4.07).
CONCLUSION
Higher post-dialysis fatigue is related to increased mortality.
引言
据报道，疲劳与透析患者的不良预后相关。本研究的目的是调查慢性血液透析患者在透析日或非透析日的疲劳是否与死亡率相关。
方法
这是一项对134例血液透析患者的前瞻性研究。使用视觉模拟量表（VAS）评估疲劳程度。研究了通过VAS值最高四分位数评估的高疲劳与全因死亡之间的关联。
结果
透析日的疲劳量表评分显著高于非透析日。在随访期间（中位时间6.8年），42例患者死亡。与低四分位数患者相比，高四分位数的透析后高疲劳患者死亡更频繁（p = 0.012）。多变量Cox回归分析表明，透析后高疲劳是全因死亡的独立预测因素（调整后的危险比2.12，95%置信区间1.10 - 4.07）。
结论
透析后较高的疲劳与死亡率增加有关。
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