Department of Translational Medicine, Lund University, Malmö, Sweden.
Institute of Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria.
BMJ Open. 2024 Jul 16;14(7):e084836. doi: 10.1136/bmjopen-2024-084836.
The Obesity and Disease Development Sweden (ODDS) study was designed to create a large cohort to study body mass index (BMI), waist circumference (WC) and changes in weight and WC, in relation to morbidity and mortality.
ODDS includes 4 295 859 individuals, 2 165 048 men and 2 130 811 women, in Swedish cohorts and national registers with information on weight assessed once (2 555 098 individuals) or more (1 740 761 individuals), in total constituting 7 733 901 weight assessments at the age of 17-103 years in 1963-2020 (recalled weight as of 1911). Information on WC is available in 152 089 men and 212 658 women, out of whom 108 795 have repeated information on WC (in total 512 273 assessments). Information on morbidity and mortality was retrieved from national registers, with follow-up until the end of 2019-2021, varying between the registers.
Among all weight assessments (of which 85% are objectively measured), the median year, age and BMI (IQR) is 1985 (1977-1994) in men and 2001 (1991-2010) in women, age 19 (18-40) years in men and 30 (26-36) years in women and BMI 22.9 (20.9-25.4) kg/m in men and 23.2 (21.2-26.1) kg/m in women. Normal weight (BMI 18.5-24.9 kg/m) is present in 67% of assessments in men and 64% in women and obesity (BMI≥30 kg/m) in 5% of assessments in men and 10% in women. The median (IQR) follow-up time from the first objectively measured or self-reported current weight assessment until emigration, death or end of follow-up is 31.4 (21.8-40.8) years in men and 19.6 (9.3-29.0) years in women. During follow-up, 283 244 men and 123 457 women died.
The large sample size and long follow-up of the ODDS Study will provide robust results on anthropometric measures in relation to risk of common diseases and causes of deaths, and novel findings in subgroups and rarer outcomes.
肥胖与疾病发展瑞典研究（ODDS）旨在创建一个大型队列，以研究体重指数（BMI）、腰围（WC）以及体重和 WC 的变化与发病率和死亡率之间的关系。
ODDS 研究包含 4295859 名个体，其中男性 2165048 人，女性 2130811 人，来自瑞典队列和国家登记处，这些个体的体重信息评估了一次（2555098 人）或多次（1740761 人），总共包括 7733901 次 17-103 岁时的体重评估（1911 年的回顾性体重）。152089 名男性和 212658 名女性的 WC 信息可用，其中 108795 人重复了 WC 信息（共 512273 次评估）。发病率和死亡率信息从国家登记处获得，随访至 2019-2021 年底，不同登记处的随访时间不同。
在所有体重评估中（其中 85%为客观测量），男性的中位数年份、年龄和 BMI（IQR）为 1985 年（1977-1994 年），女性为 2001 年（1991-2010 年），男性的年龄为 19 岁（18-40 岁），女性为 30 岁（26-36 岁），男性的 BMI 为 22.9（20.9-25.4）kg/m，女性的 BMI 为 23.2（21.2-26.1）kg/m。男性中 67%的评估为正常体重（BMI 18.5-24.9kg/m），女性中 64%的评估为正常体重，男性中 5%的评估为肥胖（BMI≥30kg/m），女性中 10%的评估为肥胖。从第一次客观测量或自我报告的当前体重评估到移民、死亡或随访结束的中位数（IQR）随访时间，男性为 31.4（21.8-40.8）年，女性为 19.6（9.3-29.0）年。随访期间，283244 名男性和 123457 名女性死亡。
ODDS 研究的大型样本量和长期随访将提供关于与常见疾病和死亡原因风险相关的人体测量指标的可靠结果，并在亚组和罕见结果中提供新的发现。
