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疟疾流行与白细胞端粒缩短有关。

Malaria endemicity linked to shorter telomeres in leukocytes.

机构信息

Centre for Human Genetics, University of Oxford, Oxford, UK.

Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.

出版信息

Trends Parasitol. 2024 Aug;40(8):660-661. doi: 10.1016/j.pt.2024.06.017. Epub 2024 Jul 15.

DOI:10.1016/j.pt.2024.06.017
PMID:39013662
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11309882/
Abstract

Leukocyte telomere length is a highly polygenic trait that has been associated with a complex range of lifestyle factors and disease risk. McQuillan et al.'s results comparing telomere length to malaria incidence rates suggest that infections may be another important factor, possibly through permanent shortening of telomeres in hematopoietic progenitor cells.

摘要

白细胞端粒长度是一个高度多基因的特征，与一系列复杂的生活方式因素和疾病风险相关。McQuillan 等人比较端粒长度与疟疾发病率的结果表明，感染可能是另一个重要因素，可能通过造血祖细胞中端粒的永久性缩短来实现。

相似文献

1
Malaria endemicity linked to shorter telomeres in leukocytes.疟疾流行与白细胞端粒缩短有关。
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本文引用的文献

1
Does Effective Population Size Govern Evolutionary Differences in Telomere Length?有效种群大小是否控制端粒长度的进化差异？
Genome Biol Evol. 2024 May 2;16(5). doi: 10.1093/gbe/evae111.
2
Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans.撒哈拉以南非洲人端粒长度与恶性疟原虫疟疾流行率之间的关联。
Am J Hum Genet. 2024 May 2;111(5):927-938. doi: 10.1016/j.ajhg.2024.04.003.
3
Genetically determined telomere length and risk for haematologic diseases: results from large prospective cohorts and Mendelian Randomization analysis.遗传决定的端粒长度与血液疾病风险：来自大型前瞻性队列研究和孟德尔随机化分析的结果。
Blood Cancer J. 2024 Mar 18;14(1):48. doi: 10.1038/s41408-024-01035-5.
4
qmotif: determination of telomere content from whole-genome sequence data.qmotif：从全基因组序列数据中确定端粒含量
Bioinform Adv. 2022 Jan 31;2(1):vbac005. doi: 10.1093/bioadv/vbac005. eCollection 2022.
5
Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study.端粒长度与心血管疾病风险：一项孟德尔随机化研究。
Front Cardiovasc Med. 2022 Oct 24;9:1012615. doi: 10.3389/fcvm.2022.1012615. eCollection 2022.
6
Modifiable traits, healthy behaviours, and leukocyte telomere length: a population-based study in UK Biobank.可改变的特征、健康行为与白细胞端粒长度：英国生物库的一项基于人群的研究。
Lancet Healthy Longev. 2022 May;3(5):e321-e331. doi: 10.1016/S2666-7568(22)00072-1.
7
Polygenic basis and biomedical consequences of telomere length variation.端粒长度变化的多基因基础和生物医学后果。
Nat Genet. 2021 Oct;53(10):1425-1433. doi: 10.1038/s41588-021-00944-6. Epub 2021 Oct 5.
8
Biomarkers of cellular aging during a controlled human malaria infection.在人为控制的疟疾感染过程中细胞衰老的生物标志物。
Sci Rep. 2021 Sep 21;11(1):18733. doi: 10.1038/s41598-021-97985-y.
9
Cellular aging dynamics after acute malaria infection: A 12-month longitudinal study.急性疟疾感染后细胞衰老动力学：一项 12 个月的纵向研究。
Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12702. Epub 2017 Nov 16.