疟疾流行与白细胞端粒缩短有关。
Malaria endemicity linked to shorter telomeres in leukocytes.
机构信息
Centre for Human Genetics, University of Oxford, Oxford, UK.
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA.
出版信息
Trends Parasitol. 2024 Aug;40(8):660-661. doi: 10.1016/j.pt.2024.06.017. Epub 2024 Jul 15.
Abstract
Leukocyte telomere length is a highly polygenic trait that has been associated with a complex range of lifestyle factors and disease risk. McQuillan et al.'s results comparing telomere length to malaria incidence rates suggest that infections may be another important factor, possibly through permanent shortening of telomeres in hematopoietic progenitor cells.
摘要
白细胞端粒长度是一个高度多基因的特征，与一系列复杂的生活方式因素和疾病风险相关。McQuillan 等人比较端粒长度与疟疾发病率的结果表明，感染可能是另一个重要因素，可能通过造血祖细胞中端粒的永久性缩短来实现。
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