Schumacher Falk, Zimmermann Maximilian, Kanbach Malte, Schulze Wigbert, Wollsching-Strobel Maximilian, Kroppen Doreen, Stanzel Sarah Bettina, Majorski Daniel, Windisch Wolfram, Strunk Johannes, Berger Melanie
Department of Rheumatology, Krankenhaus Porz am Rhein, Cologne, Germany.
Faculty of Health/School of Medicine, Witten/Herdecke University, Witten, Germany.
Arthritis Res Ther. 2024 Jul 16;26(1):132. doi: 10.1186/s13075-024-03368-9.
The increased availability of myositis autoantibodies represents new possibilities and challenges in clinical practice (Lundberg IE, Tjärnlund A, Bottai M, Werth VP, Pilkington C, de Visser M, et al. 2017 European League Against Rheumatism/American College of Rheumatology classification criteria for adult and juvenile idiopathic inflammatory myopathies and their major subgroups. Ann Rheum Dis. 2017;76:1955-64. https://doi.org/10.1136/annrheumdis-2017-211468 .). The aim of this study was to perform a retrospective data analysis of patient cases with positive myositis autoantibodies to analyse their significance in routine rheumatology practice.
A monocentric analysis of all the orders used to determine myositis autoantibodies from July 2019 to May 2022 in the Department of Rheumatology, Krankenhaus Porz am Rhein, Cologne, Germany, was carried out.
In the defined time interval, a total of 71,597 laboratory values for the antibodies mentioned above were obtained. A total of 238 different positive autoantibodies were detected in 209 patients. Idiopathic inflammatory myopathy was diagnosed in 37 patients (18%), and inflammatory rheumatic diseases other than idiopathic inflammatory myopathy were diagnosed in 90 patients (43%). No inflammatory rheumatic disease was diagnosed in 82 patients (39%). General clusters of clinical manifestations were observed.
In our cohort, we were able to show that a relevant proportion of patients with positive myositis antibodies did not have idiopathic inflammatory myopathies or inflammatory rheumatic diseases. This finding indicates the importance of myositis autoantibodies in this group of patients. However, further studies on the course of symptoms and examination results in patients without inflammatory rheumatic diseases and with positive myositis antibodies are necessary.
肌炎自身抗体检测的普及为临床实践带来了新的机遇与挑战（伦德伯格IE、蒂耶尔隆德A、博塔伊M、韦思VP、皮尔金顿C、德维瑟M等。2017年欧洲抗风湿病联盟/美国风湿病学会成人及青少年特发性炎性肌病及其主要亚组的分类标准。《风湿病学年鉴》。2017年；76:1955 - 1964。https://doi.org/10.1136/annrheumdis - 2017 - 211468 ）。本研究的目的是对肌炎自身抗体阳性的患者病例进行回顾性数据分析，以分析其在常规风湿病学实践中的意义。
对德国科隆莱茵河畔波尔茨医院风湿病科2019年7月至2022年5月期间用于检测肌炎自身抗体的所有医嘱进行单中心分析。
在规定的时间间隔内，共获得上述抗体的71,597个实验室检测值。在209例患者中检测到总共238种不同的阳性自身抗体。37例患者（18%）被诊断为特发性炎性肌病，90例患者（43%）被诊断为除特发性炎性肌病外的炎性风湿性疾病。82例患者（39%）未诊断出炎性风湿性疾病。观察到了一般的临床表现集群。
在我们的队列中，我们能够表明相当比例的肌炎抗体阳性患者没有特发性炎性肌病或炎性风湿性疾病。这一发现表明肌炎自身抗体在这组患者中的重要性。然而，有必要对无炎性风湿性疾病且肌炎抗体阳性患者的症状病程和检查结果进行进一步研究。
