用于治疗银屑病和特应性皮炎的新型芳烃受体激动剂。
Novel AHR Agonists for Treating Psoriasis and Atopic Dermatitis.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2024 Jun 21;15(7):996-997. doi: 10.1021/acsmedchemlett.4c00262. eCollection 2024 Jul 11.
Abstract
Provided herein are novel aryl hydrocarbon receptor agonists, pharmaceutical compositions, use of such compounds in treating immune-mediated diseases, in particular psoriasis and atopic dermatitis, and processes for preparing such compounds.
摘要
本文提供了新型芳烃受体激动剂、药物组合物、此类化合物在治疗免疫介导疾病（特别是银屑病和特应性皮炎）中的用途，以及制备此类化合物的方法。
相似文献
1
Novel AHR Agonists for Treating Psoriasis and Atopic Dermatitis.用于治疗银屑病和特应性皮炎的新型芳烃受体激动剂。
ACS Med Chem Lett. 2024 Jun 21;15(7):996-997. doi: 10.1021/acsmedchemlett.4c00262. eCollection 2024 Jul 11.
2
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis and Atopic Dermatitis.用于治疗银屑病和特应性皮炎的新型芳烃受体激动剂。
ACS Med Chem Lett. 2024 Nov 14;15(12):2095-2096. doi: 10.1021/acsmedchemlett.4c00537. eCollection 2024 Dec 12.
3
Novel Aryl Hydrocarbon Receptor Agonist Compounds for Treating Psoriasis and Atopic Dermatitis.用于治疗银屑病和特应性皮炎的新型芳烃受体激动剂化合物
ACS Med Chem Lett. 2025 May 16;16(6):935-936. doi: 10.1021/acsmedchemlett.5c00267. eCollection 2025 Jun 12.
4
Mapping ethical and social aspects of biomarker research and its application in atopic dermatitis and psoriasis: a systematic review of reason.绘制生物标志物研究及其在特应性皮炎和银屑病中的应用的伦理和社会方面的图谱：原因的系统综述。
J Eur Acad Dermatol Venereol. 2022 Aug;36(8):1201-1213. doi: 10.1111/jdv.18128. Epub 2022 Apr 20.
5
Defining disease severity in atopic dermatitis and psoriasis for the application to biomarker research: an interdisciplinary perspective.特应性皮炎和银屑病的疾病严重程度定义：应用于生物标志物研究的跨学科视角。
Br J Dermatol. 2024 Jun 20;191(1):14-23. doi: 10.1093/bjd/ljae080.
6
Characteristics and management of follicular events and contact dermatitis in patients using tapinarof cream for the treatment of atopic dermatitis or plaque psoriasis.使用他扎罗汀乳膏治疗特应性皮炎或斑块状银屑病患者的毛囊事件和接触性皮炎的特征与管理
J Dermatolog Treat. 2025 Dec;36(1):2517388. doi: 10.1080/09546634.2025.2517388. Epub 2025 Jul 2.
7
Novel AHR Agonists for Treating Psoriasis.用于治疗银屑病的新型芳烃受体激动剂
ACS Med Chem Lett. 2023 Apr 12;14(5):543-544. doi: 10.1021/acsmedchemlett.3c00120. eCollection 2023 May 11.
8
Novel Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, Namely, Narcolepsy and Hypersomnia.用于治疗睡眠障碍（即发作性睡病和发作性嗜睡症）的新型食欲素受体激动剂化合物。
ACS Med Chem Lett. 2024 Jul 3;15(8):1178-1179. doi: 10.1021/acsmedchemlett.4c00285. eCollection 2024 Aug 8.
9
Safety and Efficacy of Non-Steroidal Topical Aryl Hydrocarbon Receptor Agonists for the Treatment of Atopic Dermatitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.非甾体类局部芳烃受体激动剂治疗特应性皮炎的安全性和有效性：随机对照试验的系统评价和荟萃分析
Australas J Dermatol. 2025 Aug;66(5):e249-e259. doi: 10.1111/ajd.14485. Epub 2025 Apr 7.
10
Novel Ergoline Compounds as 5-HT2A Agonists for Treating Mood Disorders Such as Depressive Disorders and Bipolar Disorders.新型麦角灵化合物作为5-HT2A激动剂用于治疗情绪障碍，如抑郁症和双相情感障碍。
ACS Med Chem Lett. 2024 Dec 20;16(1):32-33. doi: 10.1021/acsmedchemlett.4c00593. eCollection 2025 Jan 9.
引用本文的文献
1
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis and Atopic Dermatitis.用于治疗银屑病和特应性皮炎的新型芳烃受体激动剂。
ACS Med Chem Lett. 2024 Nov 14;15(12):2095-2096. doi: 10.1021/acsmedchemlett.4c00537. eCollection 2024 Dec 12.
本文引用的文献
1
The role of aryl hydrocarbon receptors in nutrient metabolism and immune regulation at the maternal-fetal interface.芳香烃受体在母胎界面的营养代谢和免疫调节中的作用。
Placenta. 2024 Sep 2;154:9-17. doi: 10.1016/j.placenta.2024.05.134. Epub 2024 May 23.
2
The Psoriasis Treatment Pipeline: An Overview and Update.银屑病治疗领域的进展：概述与更新。
Dermatol Clin. 2024 Jul;42(3):365-375. doi: 10.1016/j.det.2024.02.006. Epub 2024 Mar 23.
3
Role of aryl hydrocarbon receptors in infection and inflammation.芳基烃受体在感染和炎症中的作用。
Front Immunol. 2024 Apr 12;15:1367734. doi: 10.3389/fimmu.2024.1367734. eCollection 2024.
4
The Role of Aryl Hydrocarbon Receptor in the Pathogenesis and Treatment of Psoriasis.芳烃受体在银屑病发病机制及治疗中的作用
J Cutan Med Surg. 2024 May-Jun;28(3):276-286. doi: 10.1177/12034754241239050. Epub 2024 Mar 18.
5
Novel Aryl Hydrocarbon Receptor Agonists for Treating Psoriasis.用于治疗银屑病的新型芳烃受体激动剂。
ACS Med Chem Lett. 2023 May 16;14(6):696-697. doi: 10.1021/acsmedchemlett.3c00177. eCollection 2023 Jun 8.
6
The aryl hydrocarbon receptor in immune regulation and autoimmune pathogenesis.芳香烃受体在免疫调节和自身免疫发病机制中的作用。
J Autoimmun. 2023 Jul;138:103049. doi: 10.1016/j.jaut.2023.103049. Epub 2023 May 23.
Zotero 插件