作为用于治疗多种疾病的单酰甘油脂肪酶抑制剂的新型杂环化合物。
Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases.
作者信息
Sabnis Ram W
机构信息
Smith, Gambrell & Russell LLP, 1105 W. Peachtree Street NE, Suite 1000, Atlanta, Georgia 30309, United States.
出版信息
ACS Med Chem Lett. 2024 Jun 21;15(7):994-995. doi: 10.1021/acsmedchemlett.4c00261. eCollection 2024 Jul 11.
Abstract
Provided herein are novel heterocyclic compounds as monoacylglycerol lipase inhibitors, pharmaceutical compositions, use of such compounds in treating multiple diseases and processes for preparing such compounds.
摘要
本文提供了作为单酰基甘油脂肪酶抑制剂的新型杂环化合物、药物组合物、此类化合物在治疗多种疾病中的用途以及制备此类化合物的方法。
相似文献
1
Novel Heterocyclic Compounds as Monoacylglycerol Lipase Inhibitors for Treating Multiple Diseases.作为用于治疗多种疾病的单酰甘油脂肪酶抑制剂的新型杂环化合物。
ACS Med Chem Lett. 2024 Jun 21;15(7):994-995. doi: 10.1021/acsmedchemlett.4c00261. eCollection 2024 Jul 11.
2
Novel Bicyclic Heterocyclic Compounds as CD73 Inhibitors for Treating Cancer.作为用于治疗癌症的CD73抑制剂的新型双环杂环化合物。
ACS Med Chem Lett. 2024 Dec 4;16(1):10-11. doi: 10.1021/acsmedchemlett.4c00565. eCollection 2025 Jan 9.
3
Novel Imidazopyridine and Imidazopyridazine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.新型咪唑并吡啶和咪唑并哒嗪衍生物作为治疗多种疾病的二酰甘油酰基转移酶2（DGAT2）抑制剂
ACS Med Chem Lett. 2024 Jul 3;15(8):1180-1181. doi: 10.1021/acsmedchemlett.4c00286. eCollection 2024 Aug 8.
4
Novel Triazines as NLRP3 Inhibitors for Treating Multiple Diseases.新型三嗪类化合物作为治疗多种疾病的NLRP3抑制剂
ACS Med Chem Lett. 2024 Nov 18;15(12):2099-2100. doi: 10.1021/acsmedchemlett.4c00552. eCollection 2024 Dec 12.
5
Pyrazolopyridine and Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.作为用于治疗多种疾病的二酰甘油酰基转移酶2（DGAT2）抑制剂的吡唑并吡啶和三唑并吡啶衍生物
ACS Med Chem Lett. 2024 Oct 14;15(11):1806-1807. doi: 10.1021/acsmedchemlett.4c00485. eCollection 2024 Nov 14.
6
Novel Triazolopyridine Derivatives as DGAT2 Inhibitors for Treating Multiple Diseases.作为用于治疗多种疾病的二酰甘油酰基转移酶2（DGAT2）抑制剂的新型三唑并吡啶衍生物
ACS Med Chem Lett. 2024 Aug 21;15(9):1435-1436. doi: 10.1021/acsmedchemlett.4c00408. eCollection 2024 Sep 12.
7
Novel Compounds as NLRP3 Inhibitors for Treating Cardiovascular Diseases.作为治疗心血管疾病的NLRP3抑制剂的新型化合物。
ACS Med Chem Lett. 2024 Jul 11;15(8):1184-1185. doi: 10.1021/acsmedchemlett.4c00304. eCollection 2024 Aug 8.
8
Novel Compounds as CDK2 Inhibitors for Treating Cancer.新型化合物作为治疗癌症的CDK2抑制剂
ACS Med Chem Lett. 2024 Dec 10;16(1):14-15. doi: 10.1021/acsmedchemlett.4c00574. eCollection 2025 Jan 9.
9
Novel Isoxazolidines Derivatives as RIPK1 Inhibitors for Treating Neurodegenerative Diseases.新型异恶唑烷衍生物作为用于治疗神经退行性疾病的RIPK1抑制剂
ACS Med Chem Lett. 2025 Apr 17;16(5):754-755. doi: 10.1021/acsmedchemlett.5c00197. eCollection 2025 May 8.
10
Pyrrolopyrazine Compounds as ERK5 Inhibitors for Treating Cancer.作为用于治疗癌症的细胞外信号调节激酶5（ERK5）抑制剂的吡咯并吡嗪化合物
ACS Med Chem Lett. 2024 Dec 11;16(1):16-17. doi: 10.1021/acsmedchemlett.4c00580. eCollection 2025 Jan 9.
本文引用的文献
1
Neurolipidomic insights into anxiety disorders: Uncovering lipid dynamics for potential therapeutic advances.神经脂组学对焦虑障碍的研究进展：揭示脂质动态变化以促进潜在治疗方法的发展。
Neurosci Biobehav Rev. 2024 Aug;163:105741. doi: 10.1016/j.neubiorev.2024.105741. Epub 2024 Jun 3.
2
Metabolic reprogramming in liver fibrosis.肝纤维化中的代谢重编程。
Cell Metab. 2024 Jul 2;36(7):1439-1455. doi: 10.1016/j.cmet.2024.05.003. Epub 2024 May 31.
3
Toll-like receptor signalling as a cannabinoid target.Toll 样受体信号转导作为大麻素的靶点。
Biochem Pharmacol. 2024 Apr;222:116082. doi: 10.1016/j.bcp.2024.116082. Epub 2024 Mar 2.
4
Lipid droplets provide metabolic flexibility for cancer progression.脂滴为癌症进展提供代谢灵活性。
FEBS Lett. 2024 May;598(10):1301-1327. doi: 10.1002/1873-3468.14820. Epub 2024 Feb 7.
5
Inhibiting degradation of 2-arachidonoylglycerol as a therapeutic strategy for neurodegenerative diseases.抑制 2-花生四烯酸甘油的降解作为神经退行性疾病的治疗策略。
Pharmacol Ther. 2023 Apr;244:108394. doi: 10.1016/j.pharmthera.2023.108394. Epub 2023 Mar 24.
6
Heterocyclic Compounds as Monoacylglycerol Lipase (MAGL) Inhibitors.作为单酰甘油脂肪酶（MAGL）抑制剂的杂环化合物。
ACS Med Chem Lett. 2021 Mar 31;12(4):536-537. doi: 10.1021/acsmedchemlett.1c00149. eCollection 2021 Apr 8.
Zotero 插件