Zang Xuege, Du Yongkun, Jiang Mengshu, Zhou Shiyao, Wang Libo, Han Xuemei
Department of Critical Care Medicine, China-Japan Union Hospital of Jilin University, Changchuan, Jilin, China.
Unity Health Toronto, Toronto, ON, Canada.
Front Neurol. 2024 Jul 2;15:1356974. doi: 10.3389/fneur.2024.1356974. eCollection 2024.
A growing body of evidence underscores a significant association between neurological disorders, particularly migraines, and the gut microbiota. However, a research gap persists in understanding the cause-and-effect dynamics between these elements. Therefore, we employed robust methodologies aimed at thoroughly exploring the causal relationship between the gut microbiome and migraines.
Employing bidirectional Two Sample Mendelian Randomization (TSMR) analysis, we investigated the causal association between the composition of the gut microbiota and migraines. Data summarizing the relationship between gut microbiota and migraines were extracted from one or more genome-wide association studies. The TSMR analysis employed five methods to assess the correlation between the gut microbiota and migraines, with the inverse variance-weighted method serving as the primary approach for analyzing causal links. Sensitivity analyses were applied to address horizontal pleiotropy and heterogeneity. Simultaneously, a meta-analysis was performed to strengthen the robustness of the findings. Additionally, a reverse TSMR was carried out to explore potential occurrences of reverse causal relationships.
The ongoing TSMR analysis identified a collection of 14 bacterial taxa connected to migraines. Among these, 8 taxa exhibited a protective effect, while 5 taxa had a detrimental impact, and 1 taxon maintained a neutral relationship. The reverse Mendelian randomization analysis highlighted stable outcomes for only one bacterial taxonomic group.
The study confirms a causal relationship between the gut microbiota and migraines, offering a new perspective for migraine research. Strategically targeting specific bacterial taxa with dysregulation may be effective in both preventing and treating migraines, thus opening new avenues for therapeutic strategies.
越来越多的证据强调神经系统疾病，尤其是偏头痛与肠道微生物群之间存在显著关联。然而，在理解这些因素之间的因果动态关系方面仍存在研究空白。因此，我们采用了可靠的方法，旨在全面探索肠道微生物群与偏头痛之间的因果关系。
我们采用双向两样本孟德尔随机化（TSMR）分析，研究肠道微生物群组成与偏头痛之间的因果关联。从一项或多项全基因组关联研究中提取总结肠道微生物群与偏头痛之间关系的数据。TSMR分析采用五种方法评估肠道微生物群与偏头痛之间的相关性，逆方差加权法作为分析因果关系的主要方法。应用敏感性分析来解决水平多效性和异质性问题。同时，进行荟萃分析以增强研究结果的稳健性。此外，还进行了反向TSMR分析，以探索反向因果关系的潜在发生情况。
正在进行的TSMR分析确定了14种与偏头痛相关的细菌分类群。其中，8种分类群具有保护作用，5种分类群有有害影响，1种分类群保持中性关系。反向孟德尔随机化分析仅突出了一个细菌分类组的稳定结果。
该研究证实了肠道微生物群与偏头痛之间的因果关系，为偏头痛研究提供了新的视角。针对性地调节特定失调的细菌分类群可能对预防和治疗偏头痛有效，从而为治疗策略开辟新途径。
