Krause Michael A, Grannonico Marta, Tyler Brooke P, Miller David A, Fan Weijia, Liu Mingna, Kuranov Roman V, Zhang Hao F, Liu Xiaorong, Netland Peter A
Department of Ophthalmology University of Virginia, Charlottesville, Virginia, USA.
Department of Biology University of Virginia, Charlottesville, Virginia, USA.
Case Rep Ophthalmol Med. 2024 Jul 9;2024:5823455. doi: 10.1155/2024/5823455. eCollection 2024.
Visible-light optical coherence tomography (vis-OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near-infrared (NIR) OCT systems. Here, we utilized vis-OCT to produce fibergrams (vis-OCTF) for the first time in human patients, enabling visualization and precise quantification of hyperreflective dots in the central fovea in two patients. We also directly compare the imaging qualities of conventional vis-OCT and NIR-OCT. Vis-OCT generated a 3 × 3 mm image with an impressive axial resolution of 1.3 m, whereas NIR-OCT produced an image with a larger field of view (FOV) (9 × 9 mm) but a lower resolution of 7.0 m. Moreover, vis-OCTF unveiled clear images of hyperreflective dots in the fovea of both patients, which were not discernible in the NIR-OCT images. Foveal dots have often been linked to several age-related and pathological conditions. The high-resolution images generated by vis-OCTF enable more precise characterization of changes in retinal sublayers within the central fovea.
可见光光学相干断层扫描（vis-OCT）是一种新型的非侵入性视网膜成像系统，与传统的近红外（NIR）OCT系统相比，它具有更高的分辨率。在此，我们首次在人类患者中利用vis-OCT生成纤维图（vis-OCTF），从而能够可视化并精确量化两名患者中央凹中的高反射点。我们还直接比较了传统vis-OCT和NIR-OCT的成像质量。vis-OCT生成了一幅3×3毫米的图像，其轴向分辨率高达1.3微米，而NIR-OCT生成的图像视野更大（9×9毫米），但分辨率较低，为7.0微米。此外，vis-OCTF揭示了两名患者中央凹中高反射点的清晰图像，而这些在NIR-OCT图像中是无法辨别的。中央凹点常常与多种年龄相关和病理状况有关。vis-OCTF生成的高分辨率图像能够更精确地表征中央凹内视网膜各亚层的变化。
