Preis P, Luger A, Templ H, Tragl H K, Geyer G
Z Gerontol. 1985 Jul-Aug;18(4):241-3.
Because of the decreased dopamine concentration in the elderly brain an alteration of the dopaminergic suppression of aldosterone and prolactin incretion was postulated. In contrast, the application of the dopamine D2-antagonist metoclopramide showed no significant difference as to the blockade of this dopaminergic suppression in two groups of patients with a mean age of 40 and 80 years. Subsequently aldosterone and prolactin incretion was equally stimulated in both groups.
由于老年人大脑中多巴胺浓度降低，推测多巴胺能对醛固酮和催乳素分泌的抑制作用发生了改变。相比之下，多巴胺D2拮抗剂甲氧氯普胺在平均年龄为40岁和80岁的两组患者中应用时，对这种多巴胺能抑制的阻断作用并无显著差异。随后，两组中醛固酮和催乳素的分泌均受到同等程度的刺激。
