Akbari Atieh, Behravan Parisa, Moradi Afshin, Akbari Mohammad Esmaeil
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Case Rep Oncol. 2024 Jun 3;17(1):608-613. doi: 10.1159/000538771. eCollection 2024 Jan-Dec.
Granular cell tumors (GCTs) are uncommon, low-grade Schwann cell tumors found in the skin, soft tissue, and mucosal surfaces of the oral, gastrointestinal, and respiratory tracts. One in 1,000 breast cancer cases is GCT. Just 1-2% of GCTs are malignant GCTs.
This case report presents the clinical details and outcomes of a 34-year-old woman with a main concern of a palpable mass and pain in her right breast. In the clinical examination, we found a 1.5 × 2-cm palpable mass in her right breast with no axillary lymph node detection. The primary diagnosis was a benign GCT mimicking carcinoma of the breast. Upon evaluation, the mass was confirmed to be a benign GCT through pathology. The patient underwent breast-conserving surgery and sentinel lymph node dissection at the Cancer Research Center of Shahid Beheshti University of Medical Sciences on November 30, 2022. The surgical margins were found to be free of tumors, and there was no involvement of skin or axillary lymph nodes. The patient had a positive postoperative outcome, with no complications observed.
The case highlights the importance of accurate diagnosis and appropriate surgical planning to avoid invasive procedures and unnecessary radical surgeries in cases of benign GCT mimicking carcinoma of the breast.
颗粒细胞瘤（GCTs）是一种罕见的低级别施万细胞瘤，见于皮肤、软组织以及口腔、胃肠道和呼吸道的黏膜表面。每1000例乳腺癌病例中有1例是颗粒细胞瘤。颗粒细胞瘤中仅有1%-2%为恶性颗粒细胞瘤。
本病例报告呈现了一名34岁女性的临床细节及治疗结果，其主要诉求为右乳可触及肿块及疼痛。临床检查发现，其右乳有一个1.5×2厘米的可触及肿块，未检测到腋窝淋巴结。初步诊断为疑似乳腺癌的良性颗粒细胞瘤。经评估，通过病理检查确诊该肿块为良性颗粒细胞瘤。2022年11月30日，该患者在沙希德·贝赫什提医科大学癌症研究中心接受了保乳手术及前哨淋巴结清扫术。手术切缘未见肿瘤，皮肤及腋窝淋巴结未受累。患者术后恢复良好，未观察到并发症。
该病例凸显了准确诊断及合理手术规划的重要性，以避免在疑似乳腺癌的良性颗粒细胞瘤病例中进行侵入性手术及不必要的根治性手术。
