Mohebbi Alireza, Babaei Mohammadreza, Zahabi Elham, Safi Dahaj Farzan, Roomiani Maryam
ENT and Head and Neck Research Center and Department, Hazrat Rasoul Akram Hospital, The Five Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Department of Interventional Radiology, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran.
Iran J Otorhinolaryngol. 2024 Jul;36(4):507-515. doi: 10.22038/IJORL.2024.78179.3628.
Diced cartilage grafts are well-liked, dependable, and simple-to-use techniques for dorsum camouflage in rhinoplasty. Recent research results demonstrate how effectively PRF increases the survivability of diced cartilage in the nasal dorsum and decreases its absorption. In this study, we intend to investigate the effect of fibrin-rich platelets (PRF) on diced cartilage survival in rhinoplasty surgery.
This clinical trial included people referred to Rasoul Akram Hospital for rhinoplasty between 2020 and 2021. Patients were divided into two groups: Diced Cartilage alone (DC) and Diced Cartilage + PRF (DC+PRF). Cartilage survival was assessed by ultrasound, photography, and nasal examination, and the two groups were compared six months after rhinoplasty. Patients' satisfaction with surgery was also evaluated using the Utrecht questionnaire.
The mean age of the two groups of 20 patients was 29.05 ± 7.02 and 26.65 ± 8.16 years in the DC and DC + PRF groups, respectively (P>0.05). After treatment, the frequency of irregularity on examination and dissatisfaction score was slightly but insignificantly higher in the DC group compared to the DC + PRF group (25% vs. 15% and 12.25 ± 6.45 vs. 10.45 ± 6.74, respectively, and P values>0.05). The total volume decrease, regardless of the injection site, was significant in both groups (P < 0.05), but the magnitude of volume reduction was significantly higher in the DC group compared to the DC + PRF group (-0.060 ± 0.087 vs. - 0.033±0.017, respectively, P<0.05).
PRF may slow down the absorption process of diced cartilage.
在鼻整形术中，碎软骨移植是一种广受欢迎、可靠且易于使用的鼻背掩饰技术。最近的研究结果表明，富血小板纤维蛋白（PRF）能有效提高碎软骨在鼻背的存活率并减少其吸收。在本研究中，我们旨在探讨富血小板纤维蛋白（PRF）对鼻整形手术中碎软骨存活的影响。
本临床试验纳入了2020年至2021年间因鼻整形术转诊至拉苏勒·阿克拉姆医院的患者。患者分为两组：单纯碎软骨组（DC）和碎软骨+PRF组（DC+PRF）。通过超声、摄影和鼻腔检查评估软骨存活情况，并在鼻整形术后六个月对两组进行比较。还使用乌得勒支问卷评估患者对手术的满意度。
两组各20例患者的平均年龄，DC组为29.05±7.02岁，DC+PRF组为26.65±8.16岁（P>0.05）。治疗后，检查时不规则情况的发生率和不满意评分，DC组略高于DC+PRF组，但差异无统计学意义（分别为25%对15%，以及12.25±6.45对10.45±6.74，P值>0.05）。无论注射部位如何，两组的总体积减少均有统计学意义（P<0.05），但DC组的体积减少幅度明显高于DC+PRF组（分别为-0.060±0.087对-0.033±0.017，P<0.05）。
PRF可能会减缓碎软骨的吸收过程。
