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局部直肠切除术的当前手术方法。

Current Surgical Methods in Local Rectal Excision.

作者信息

Šemanjski Kristina, Lužaić Karla, Brkić Jure

机构信息

Department of Surgery, Clinical Hospital Sveti Duh, Zagreb, Croatia.

Institute of Emergency Medicine of Sisak - Moslavina County, Sisak, Croatia.

出版信息

Gastrointest Tumors. 2024 Apr 17;10(1):44-56. doi: 10.1159/000538958. eCollection 2023 Jan-Dec.

DOI:10.1159/000538958
PMID:39015761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11249472/
Abstract

BACKGROUND

The treatment of rectal cancer has evolved with the advancement of surgical techniques. Less invasive approaches are becoming more accepted as the primary treatment method.

SUMMARY

Such methods as transanal excision, transanal endoscopic microsurgery, and transanal minimally invasive surgery can reduce morbidity and mortality rates. However, not all patients are suitable candidates for these procedures, and proper diagnostics are necessary to establish indications. Compared to total mesorectal excision, transanal excision techniques have been shown to have fewer complications and comorbidities while still being able to remove cancerous tissue entirely. Transanal excision is the simplest method, where the operator removes visible rectal lesions. The basic principle of transanal endoscopic microsurgery is to dilate the rectum mechanically and by air insufflation and then use special surgical instruments to remove suspicious lesions under the vision of a telescope. Transanal minimally invasive surgery combines transanal endoscopic microsurgery and single-incision laparoscopic surgery, making the hard-to-reach proximal rectum accessible to classic laparoscopic instruments.

KEY MESSAGE

Local excision techniques, when used as a monotherapy for treating patients with rectal cancer, have established themselves as a curative and less radical treatment for strictly selected patients with early rectal carcinoma, leading to improved quality of life. When combined with other modalities such as neoadjuvant chemoradiotherapy, total neoadjuvant therapy, and immunotherapy, transanal surgery can be offered to patients with locally advanced rectal cancer as part of the organ preservation strategy. This review will discuss the patient selection and technical aspects of transanal surgery, showcasing its current role in treating rectal carcinoma.

摘要

背景

随着手术技术的进步,直肠癌的治疗方法不断演变。侵入性较小的方法作为主要治疗手段越来越被接受。

总结

经肛门切除术、经肛门内镜显微手术和经肛门微创手术等方法可降低发病率和死亡率。然而,并非所有患者都适合这些手术,需要进行适当的诊断以确定适应症。与全直肠系膜切除术相比,经肛门切除技术已被证明并发症和合并症更少,同时仍能完全切除癌组织。经肛门切除术是最简单的方法,手术者可切除可见的直肠病变。经肛门内镜显微手术的基本原理是通过机械扩张和气体注入使直肠扩张,然后在望远镜视野下使用特殊手术器械切除可疑病变。经肛门微创手术结合了经肛门内镜显微手术和单切口腹腔镜手术,使经典腹腔镜器械能够触及难以到达的直肠近端。

关键信息

局部切除技术作为直肠癌患者的单一治疗方法,已成为严格选择的早期直肠癌患者的一种治愈性且创伤较小的治疗方法,可提高生活质量。当与新辅助放化疗、全新辅助治疗和免疫治疗等其他方式联合使用时,经肛门手术可作为器官保留策略的一部分提供给局部晚期直肠癌患者。本综述将讨论经肛门手术的患者选择和技术方面,展示其目前在治疗直肠癌中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/8d3381d2cb26/gat-2023-0010-0001-538958_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/3eaa4ec8fe1c/gat-2023-0010-0001-538958_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/39094c348224/gat-2023-0010-0001-538958_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/98dea980f907/gat-2023-0010-0001-538958_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/830cbc439a50/gat-2023-0010-0001-538958_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/8d3381d2cb26/gat-2023-0010-0001-538958_F05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/3eaa4ec8fe1c/gat-2023-0010-0001-538958_F01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/39094c348224/gat-2023-0010-0001-538958_F02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/98dea980f907/gat-2023-0010-0001-538958_F03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/830cbc439a50/gat-2023-0010-0001-538958_F04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4da1/11249472/8d3381d2cb26/gat-2023-0010-0001-538958_F05.jpg

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本文引用的文献

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Ann Coloproctol. 2023 Aug;39(4):301-306. doi: 10.3393/ac.2023.00269.0038. Epub 2023 Aug 29.
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Trends of Colorectal Cancer Incidence, Prevalence and Mortality in Worldwide From 1990 to 2017.1990年至2017年全球结直肠癌发病率、患病率和死亡率趋势
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Emerging evidence of immunotherapy for colorectal cancer.结直肠癌免疫治疗的新证据。
Ann Gastroenterol Surg. 2022 Nov 8;7(2):216-224. doi: 10.1002/ags3.12633. eCollection 2023 Mar.
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Front Immunol. 2022 Dec 8;13:1067036. doi: 10.3389/fimmu.2022.1067036. eCollection 2022.
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The Evolving Landscape of Immunotherapy in Locally Advanced Rectal Cancer Patients.局部晚期直肠癌患者免疫治疗的发展态势
Cancers (Basel). 2022 Sep 14;14(18):4453. doi: 10.3390/cancers14184453.
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Anti-PD-1-based immunotherapy as curative-intent treatment in dMMR/MSI-H rectal cancer: A multicentre cohort study.抗 PD-1 免疫治疗作为错配修复缺陷/微卫星高度不稳定直肠癌的根治性治疗:一项多中心队列研究。
Eur J Cancer. 2022 Oct;174:176-184. doi: 10.1016/j.ejca.2022.07.016. Epub 2022 Aug 26.
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Neoadjuvant Chemotherapy, Excision, and Observation for Early Rectal Cancer: The Phase II NEO Trial (CCTG CO.28) Primary End Point Results.新辅助化疗、切除与观察治疗早期直肠癌:Ⅱ期 NEO 试验(CCTG CO.28)主要终点结果。
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