Hong Yan, Jin Xia, Shi Lihong
Department of Traditional Chinese Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Gynaecology and Obstetrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China.
Front Psychiatry. 2024 Jul 2;15:1345815. doi: 10.3389/fpsyt.2024.1345815. eCollection 2024.
Identifying possible influencing factors is crucial for the depression symptoms of women experiencing infertility. This study aims to explore the association between polyunsaturated fatty acids (PUFAs) and the odds of depression symptoms in women experiencing infertility.
This is a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES). PUFA intake was obtained through a 24-h dietary recall interview. Depression symptoms were defined using the Patient Health Questionnaire-9 (PHQ-9) with a score of ≥10 points or as taking antidepressants. The association between PUFA and depression was assessed using a logistic regression model by calculating the odds ratio (OR) with 95% confidence interval (CI). Subgroup analysis was carried out based on menopausal status and female hormone use.
There were 725 participants included for analysis. After adjusting the covariables, lower odds of depression symptoms were found in patients with the intake of omega-3 PUFA (OR = 0.48, 95% CI: 0.24-0.96) and omega-6 PUFA (OR = 0.24, 95% CI: 0.14-0.42) in the second tertile (T2) in comparison to the first tertile (T1). The intake of α-linolenic (ALA) (OR = 0.48, 95% CI: 0.23-0.97) and linoleic acid (OR = 0.24, 95% CI: 0.14-0.41) in T2 was also found to be related to the reduced odds of depression symptoms in comparison to T1.
Our findings suggest a potential association between moderate omega-3 and omega-6 PUFA intake and a reduced risk of depression symptoms in women experiencing infertility. This implies that clinicians might find it useful to consider dietary advice that includes PUFA-rich foods as part of a broader strategy to address mental health in this patient group. However, further research is needed to confirm these preliminary findings and to establish the optimal levels of PUFA intake for mental health benefits.
识别可能的影响因素对于不孕女性的抑郁症状至关重要。本研究旨在探讨多不饱和脂肪酸（PUFAs）与不孕女性抑郁症状发生几率之间的关联。
这是一项基于美国国家健康与营养检查调查（NHANES）的横断面研究。通过24小时饮食回顾访谈获取PUFA摄入量。抑郁症状采用患者健康问卷-9（PHQ-9）进行定义，得分≥10分或正在服用抗抑郁药。使用逻辑回归模型通过计算比值比（OR）及95%置信区间（CI）来评估PUFA与抑郁之间的关联。基于绝经状态和女性激素使用情况进行亚组分析。
共有725名参与者纳入分析。在调整协变量后，与第一三分位数（T1）相比，处于第二三分位数（T2）的摄入ω-3 PUFA（OR = 0.48，95% CI：0.24 - 0.96）和ω-6 PUFA（OR = 0.24，95% CI：0.14 - 0.42）的患者出现抑郁症状的几率较低。与T1相比，T2中α-亚麻酸（ALA）（OR = 0.48，95% CI：0.23 - 0.97）和亚油酸（OR = 0.24，95% CI：0.14 - 0.41）的摄入也与抑郁症状几率降低有关。
我们的研究结果表明，适度摄入ω-3和ω-6 PUFAs与不孕女性抑郁症状风险降低之间可能存在关联。这意味着临床医生可能会发现，将包含富含PUFA食物的饮食建议作为解决该患者群体心理健康问题的更广泛策略的一部分是有用的。然而，需要进一步研究来证实这些初步发现，并确定对心理健康有益的PUFA最佳摄入量。
