Osuna Ester, Symington Elizabeth A, Malan Linda, Ricci Cristian, Zandberg Lizelle, Smuts Cornelius M, Baumgartner Jeannine
Laboratory of Human Nutrition, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland.
Department of Life and Consumer Sciences, University of South Africa, Johannesburg, South Africa.
Prostaglandins Leukot Essent Fatty Acids. 2023 Mar;190:102528. doi: 10.1016/j.plefa.2022.102528. Epub 2023 Jan 13.
Perinatal depression can negatively affect the health of the mother and her offspring. N-3 polyunsaturated fatty acids (PUFA) may play a role in the aetiology of depression. Therefore, we investigated the association of n-3 PUFA status during early pregnancy with perinatal depression among women living in urban Johannesburg, South Africa. For this prospective analysis, we analysed red blood cell (RBC) total phospholipid fatty acid (FA) composition (% of total FA) of 242 pregnant women at <18 weeks' gestation. We used the Edinburgh Postnatal Depression Scale (EPDS) to identify women at risk for depression (EPDS score ≥9) at <18, 22 and 36 weeks' gestation, and at 6 and 12 months postpartum. RBC EPA status was negatively (β=-0.22, p<0.05), and the AA/EPA ratio positively (β=0.24, p<0.05) associated with EPDS scores at 12 months postpartum. Higher RBC DHA and n-3 index were further associated with lower odds (OR=0.56 [95% CI: 0.32-0.91]; OR=0.63 [95% CI: 0.39-0.94]), while higher n-6/n-3 PUFA and AA/EPA ratios early in pregnancy were associated with higher odds for depression at 12 months postpartum ((OR=2.34 [95% CI: 1.12-4.97]; OR=1.02 [95% CI: 1.00-1.05]). Our results suggest that women with a higher RBC n-3 PUFA status during early pregnancy may be at lower risk for depression at 12 months postpartum.
围产期抑郁症会对母亲及其后代的健康产生负面影响。n-3多不饱和脂肪酸（PUFA）可能在抑郁症的病因中起作用。因此，我们调查了南非约翰内斯堡市区女性孕早期n-3 PUFA状态与围产期抑郁症之间的关联。在这项前瞻性分析中，我们分析了242名妊娠<18周孕妇的红细胞（RBC）总磷脂脂肪酸（FA）组成（占总FA的百分比）。我们使用爱丁堡产后抑郁量表（EPDS）来确定妊娠<18周、22周和36周以及产后6个月和12个月有抑郁风险（EPDS评分≥9）的女性。产后12个月时，红细胞EPA状态与EPDS评分呈负相关（β=-0.22，p<0.05），而AA/EPA比值与EPDS评分呈正相关（β=0.24，p<0.05）。较高的红细胞DHA和n-3指数还与较低的抑郁几率相关（OR=0.56 [95% CI：0.32-0.91]；OR=0.63 [95% CI：0.39-0.94]），而孕早期较高的n-6/n-3 PUFA和AA/EPA比值与产后12个月较高的抑郁几率相关（OR=2.34 [95% CI：1.12-4.97]；OR=1.02 [95% CI：1.00-1.05]）。我们的结果表明，孕早期红细胞n-3 PUFA状态较高的女性在产后12个月患抑郁症的风险可能较低。
