Zheng Yu-Ping, He Xu-Feng, Zhang Yan-Feng, Geng Lan-Xin, Zhang Hui-Min, Wan Hua, He Xiang
Department of Dermatology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Department of Galactophore, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
World J Clin Cases. 2024 Jul 16;12(20):4180-4190. doi: 10.12998/wjcc.v12.i20.4180.
Rhinophyma, a late-stage subtype of rosacea, is characterized by excessive sebaceous glands and connective tissue proliferation. Patients may experience respiratory disturbances and psychological distress that significantly affect their quality of life when excessive nasal hyperplasia obstructs the external nasal valves. Surgery is the treatment of choice for rhinophyma. However, excessive bleeding, scarring, pigmentation, and high recurrence rates frequently characterize current surgical methods.
To evaluate the clinical effectiveness and recurrence rates after treating severe rhinophyma with the five-blade scratcher.
This study retrospectively analyzed the clinical records of 28 patients with severe rhinophyma rosacea. The Global Flushing Severity Score (GFSS), Clinician Erythema Assessment (CEA), Rhinophyma Severity Index (RHISI), Glasgow Benefit Inventory (GBI), and satisfaction scores were used to assess the recovery of patients at 6 months and 5 years, with the recurrence rate calculated at 5 years postoperatively. In addition, the levels of pro-inflammatory factors (TNF-α, IL-1β, and IL-6) in the serum of patients before and after surgery were detected by ELISA.
The GFSS, CEA, and RHISI scores at 6 months and 5 years postoperatively were significantly lower than those preoperatively ( < 0.001 for both periods). Five-blade scratcher treatment greatly benefits patients as demonstrated by the GBI and patient satisfaction. A small number of patients (7/28, 25%) reported recurrence after surgical treatment for rhinophyma in our department that was not more serious than before treatment. The expression of pro-inflammatory factors (TNF-α, IL-1β, and IL-6) in the patient's serum was significantly reduced after surgery of five-blade scratcher.
The five-blade scratcher treatment demonstrates notable advantages, including simplicity, safety, efficacy, and cost-effectiveness, coupled with reduced bleeding, minimized scarring, lower recurrence rates, reduced the level of pro-inflammatory factors and improved patient satisfaction. Consequently, this therapeutic modality exhibits a viable option for individuals afflicted with severe rhinophyma.
酒渣鼻的晚期亚型鼻赘,其特征为皮脂腺和结缔组织过度增生。当鼻赘过度增生阻塞鼻外阀时,患者可能会出现呼吸障碍和心理困扰,这会显著影响他们的生活质量。手术是鼻赘的首选治疗方法。然而,目前的手术方法常常存在出血过多、瘢痕形成、色素沉着以及复发率高等问题。
评估五刃刮除器治疗重度鼻赘后的临床疗效和复发率。
本研究回顾性分析了28例重度酒渣鼻鼻赘患者的临床记录。采用全球潮红严重程度评分(GFSS)、临床医师红斑评估(CEA)、鼻赘严重程度指数(RHISI)、格拉斯哥获益量表(GBI)和满意度评分来评估患者在6个月和5年时的恢复情况,并计算术后5年的复发率。此外,通过酶联免疫吸附测定法检测患者手术前后血清中促炎因子(TNF-α、IL-1β和IL-6)的水平。
术后6个月和5年时的GFSS、CEA和RHISI评分均显著低于术前(两个时期均P<0.001)。五刃刮除器治疗对患者有很大益处,GBI和患者满意度均表明了这一点。在我们科室,少数患者(7/28,25%)在鼻赘手术治疗后报告有复发,但不比治疗前严重。五刃刮除器手术后患者血清中促炎因子(TNF-α、IL-1β和IL-6)的表达明显降低。
五刃刮除器治疗具有显著优势,包括操作简单、安全、有效、性价比高,同时出血减少、瘢痕形成最小化、复发率降低、促炎因子水平降低以及患者满意度提高。因此,这种治疗方式为患有重度鼻赘的患者提供了一种可行的选择。