Cao Jianing, Yang Mengdi, Guo Duancheng, Tao Zhonghua, Hu Xichun
Department of Breast and Urologic Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.
Cancer Med. 2024 Jul;13(14):e7472. doi: 10.1002/cam4.7472.
Breast cancer (BC) is the most common malignant tumor worldwide. Despite enormous progress made in the past decades, the underlying mechanisms of BC remain further illustrated. Recently, TRIM family proteins proved to be engaged in BC progression through regulating various aspects. Here we reviewed the structures and basic functions of TRIM family members and first classified them into three groups according to canonical polyubiquitination forms that they could mediate: K48- only, K63- only, and both K48- and K63-linked ubiquitination. Afterwards, we focused on the specific biological functions and mechanisms of TRIMs in BCs, including tumorigenesis and invasiveness, drug sensitivity, tumor immune microenvironment (TIME), cell cycle, and metabolic reprogramming. We also explored the potential of TRIMs as novel biomarkers for predicting prognosis and future therapeutic targets in BC.
乳腺癌（BC）是全球最常见的恶性肿瘤。尽管在过去几十年中取得了巨大进展，但BC的潜在机制仍有待进一步阐明。最近，TRIM家族蛋白被证明通过调节多个方面参与BC的进展。在此，我们综述了TRIM家族成员的结构和基本功能，并首先根据它们能够介导的典型多聚泛素化形式将其分为三组：仅K48连接、仅K63连接以及K48和K63连接的泛素化。之后，我们重点关注了TRIMs在BC中的特定生物学功能和机制，包括肿瘤发生和侵袭性、药物敏感性、肿瘤免疫微环境（TIME）、细胞周期和代谢重编程。我们还探讨了TRIMs作为预测BC预后的新型生物标志物和未来治疗靶点的潜力。
