用反相高效液相色谱法（RP-HPLC）估算细胞周期蛋白依赖性激酶抑制剂：在与质子泵抑制剂（PPIs）的药代动力学相互作用研究中的应用。
Estimation of CDK inhibitors by RP-HPLC: application for pharmacokinetic interactions studies with PPIs.
机构信息
Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
出版信息
Bioanalysis. 2024;16(15):801-812. doi: 10.1080/17576180.2024.2372162. Epub 2024 Jul 17.
The study investigated pharmacokinetic interactions between palbociclib and ribociclib with proton pump inhibitors (PPIs) using the reverse-phase high-performance liquid chromatography (RP-HPLC) method. Developed RP-HPLC method quantified palbociclib and ribociclib in biological matrices. metabolic stability assays and studies in rats evaluated effect of omeprazole and esomeprazole on pharmacokinetics of palbociclib and ribociclib. The RP-HPLC method was sensitive, accurate and linear. Esomeprazole and omeprazole decreased metabolic clearance of palbociclib and ribociclib by several folds. , esomeprazole elevated C of palbociclib and ribociclib by 90.1% and 86.4%, whereas omeprazole reduced it by 32.0% and 16.8%, respectively. The RP-HPLC method was used to analyze and samples. Long-term treatment with PPIs affects pharmacokinetics of palbociclib and ribociclib, necessitating optimal chemotherapy regimen.
本研究采用反相高效液相色谱（RP-HPLC）法研究了帕博西尼和瑞博西尼与质子泵抑制剂（PPIs）之间的药代动力学相互作用。所开发的 RP-HPLC 方法定量了生物基质中的帕博西尼和瑞博西尼。代谢稳定性测定和大鼠研究评估了奥美拉唑和埃索美拉唑对帕博西尼和瑞博西尼药代动力学的影响。RP-HPLC 方法灵敏、准确且线性。埃索美拉唑和奥美拉唑使帕博西尼和瑞博西尼的代谢清除率降低了数倍。此外，埃索美拉唑使帕博西尼和瑞博西尼的 C 增加了 90.1%和 86.4%，而奥美拉唑分别降低了 32.0%和 16.8%。该 RP-HPLC 方法用于分析 和 样本。长期使用 PPIs 会影响帕博西尼和瑞博西尼的药代动力学，需要优化化疗方案。
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