Rageh Mahmoud A, Fathi Mostafa Khairy, Ibrahim Shady Mahmoud Attia
All authors are affiliated with the Department of Dermatology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Dermatol Surg. 2025 Jan 1;51(1):40-45. doi: 10.1097/DSS.0000000000004322. Epub 2024 Jul 17.
Burn scars are considered one of the challenging issues that can affect the quality of life by causing aesthetic and functional problems. Injecting nanofat particles, which are considered a source of stem cells, into the dermis and/or subcutis of the burned area is considered a promising procedure for the treatment of scars and the correction of volume shortage and skin renewal.
To assess the safety and effectiveness of using autologous nanofat injections to treat burn scars.
Thirty patients with postburn scars participated in the trial. Each patient received one session of liposuction, which was then converted into nanofat and injected back into the scar tissue. Four months after the session, the evaluation was conducted both objectively using the Antera camera 3D imaging and subjectively using the Vancouver scar scale (VSS).
Because there were statistically significant improvements in the treated scars' height, color, vascularity, and pliability, the total VSS scores differed significantly before and after treatment. Furthermore, the Antera 3D imaging revealed a statistically significant variation in the treated scars' indentations, erythema, and pigmentation scores.
The study findings demonstrated that nanofat is a successful postburn scar treatment option that improves patients' quality of life.
烧伤疤痕被认为是具有挑战性的问题之一，会因造成美观和功能问题而影响生活质量。将被视为干细胞来源的纳米脂肪颗粒注射到烧伤区域的真皮层和/或皮下组织，被认为是治疗疤痕、纠正体积不足和促进皮肤更新的一种有前景的方法。
评估使用自体纳米脂肪注射治疗烧伤疤痕的安全性和有效性。
30例烧伤后疤痕患者参与了该试验。每位患者接受一次抽脂手术，然后将抽出的脂肪转化为纳米脂肪并注射回疤痕组织。手术四个月后，使用Antera相机3D成像进行客观评估，并使用温哥华疤痕量表（VSS）进行主观评估。
由于治疗后的疤痕在高度、颜色、血管分布和柔韧性方面有统计学上的显著改善，治疗前后的VSS总分有显著差异。此外，Antera 3D成像显示治疗后的疤痕在凹陷、红斑和色素沉着评分方面有统计学上的显著差异。
研究结果表明，纳米脂肪是一种成功的烧伤后疤痕治疗选择，可改善患者的生活质量。
