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通过分子监测首次在意大利儿童侵袭性感染中发现化脓性链球菌M1英国克隆株的证据。

First Evidence of Streptococcus pyogenes M1 UK Clone in Pediatric Invasive Infections in Italy by Molecular Surveillance.

作者信息

Vrenna Gianluca, Rossitto Martina, Agosta Marilena, Cortazzo Venere, Fox Valeria, De Luca Maia, Lancella Laura, Gargiullo Livia, Granaglia Annarita, Fini Vanessa, Yu La Rosa Katia, Argentieri Marta, Pansani Laura, Sisto Annamaria, Raponi Massimiliano, Villani Alberto, Perno Carlo Federico, Bernaschi Paola

机构信息

From the Multimodal Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

出版信息

Pediatr Infect Dis J. 2024 Nov 1;43(11):e421-e424. doi: 10.1097/INF.0000000000004455. Epub 2024 Jul 16.

DOI:10.1097/INF.0000000000004455
PMID:39018473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11460761/
Abstract

Invasive group A streptococci infections are increasing worldwide, mainly due to the emm1 lineage M1 UK emergence. Although this variant has recently been described in adult Italian patients, its circulation in children has not yet been established. Characterizing by whole genome sequencing 6 invasive group A streptococci strains isolated between 2022 and 2023, we highlighted M1 UK lineage circulation in pediatric patients in Italy.

摘要

侵袭性A组链球菌感染在全球范围内呈上升趋势，主要原因是emm1谱系M1英国株的出现。尽管这种变体最近在成年意大利患者中已有描述，但其在儿童中的传播情况尚未明确。通过对2022年至2023年间分离出的6株侵袭性A组链球菌菌株进行全基因组测序分析，我们发现M1英国谱系在意大利儿科患者中存在传播。

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本文引用的文献

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Front Microbiol. 2024 Jan 11;14:1287522. doi: 10.3389/fmicb.2023.1287522. eCollection 2023.
2
Characterization of emergent toxigenic M1 and associated sublineages.鉴定出具有潜在毒性的 M1 型及其相关亚系。
Microb Genom. 2023 Apr;9(4). doi: 10.1099/mgen.0.000994.
3
Group A Streptococcal Meningitis With the M1UK Variant in the Netherlands.荷兰出现带有M1UK变异株的A组链球菌性脑膜炎。
JAMA. 2023 May 23;329(20):1791-1792. doi: 10.1001/jama.2023.5927.
4
Emerging Invasive Group A Streptococcus M1 Lineage Detected by Allele-Specific PCR, England, 2020.2020 年英格兰通过等位基因特异性 PCR 检测到的侵袭性 A 组链球菌 M1 谱系。
Emerg Infect Dis. 2023 May;29(5):1007-1010. doi: 10.3201/eid2905.221887. Epub 2023 Apr 5.
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Pathogenesis, epidemiology and control of Group A Streptococcus infection.A 组链球菌感染的发病机制、流行病学和控制。
Nat Rev Microbiol. 2023 Jul;21(7):431-447. doi: 10.1038/s41579-023-00865-7. Epub 2023 Mar 9.
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