Department of Obstetrics and Gynecology, Kayseri City Hospital, Kayseri, Turkey.
Department of Obstetrics and Gynecology, Kayseri City Hospital, Kayseri, Turkey.
Placenta. 2024 Sep 2;154:176-183. doi: 10.1016/j.placenta.2024.07.002. Epub 2024 Jul 3.
The aim of the present study was to evaluate the effects of different polycystic ovary syndrome (PCOS) phenotypes using first-trimester placental three-dimensional power Doppler indices and placental volume.
In this prospective case-control study, 170 pregnant women who met the inclusion criteria were divided into five groups according to PCOS phenotype: non-PCOS control (n = 34), PCOS phenotype A (n = 34), PCOS phenotype B (n = 34), PCOS phenotype C (n = 34), and PCOS phenotype D (n = 34). The primary outcomes determined in the present study were the differences in placental volume and placental flow index (FI), vascularization flow index (VFI), vascularization index (VI), and uterine artery pulsatility index (PI) betweenthe PCOS groups and control group.
The mean placental volume and VI were significantly decreased in the phenotype A, B, and C groups compared to the control group and PCOS phenotype D group. The mean FI and VFI were significantly decreased in the phenotype A and B groups compared to the control group and PCOS phenotype C and D groups. The mean testosterone, dehydroepiandrostenedione, sex-hormone binding globulin, free androgen index, and insulin resistance levels were significantly increased in the phenotype A, B, and C groups compared to the control group and PCOS phenotype D group.
The results indicated that placental volume and placental vascular Doppler indices in the first trimester were more adversely affected in the PCOS A and B phenotypes than other PCOS phenotypes.
本研究旨在通过早孕期胎盘三维能量多普勒指数和胎盘体积评估不同多囊卵巢综合征（PCOS）表型的影响。
在这项前瞻性病例对照研究中，根据 PCOS 表型将 170 名符合纳入标准的孕妇分为五组：非 PCOS 对照组（n=34）、PCOS 表型 A（n=34）、PCOS 表型 B（n=34）、PCOS 表型 C（n=34）和 PCOS 表型 D（n=34）。本研究的主要结局是比较 PCOS 组和对照组之间胎盘体积和胎盘血流指数（FI）、血管化血流指数（VFI）、血管化指数（VI）和子宫动脉搏动指数（PI）的差异。
与对照组和 PCOS 表型 D 组相比，表型 A、B 和 C 组的胎盘体积和 VI 平均值显著降低。与对照组和 PCOS 表型 C 和 D 组相比，表型 A 和 B 组的 FI 和 VFI 平均值显著降低。与对照组和 PCOS 表型 D 组相比，表型 A、B 和 C 组的睾酮、脱氢表雄酮、性激素结合球蛋白、游离雄激素指数和胰岛素抵抗水平显著升高。
结果表明，与其他 PCOS 表型相比，早孕期胎盘体积和胎盘血管多普勒指数在 PCOS A 和 B 表型中受到更不利的影响。
