Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711, USA.
Daniels College of Business, Denver University, 2101 S. University Blvd., Denver, CO 80208, USA.
Drug Discov Today. 2024 Sep;29(9):104103. doi: 10.1016/j.drudis.2024.104103. Epub 2024 Jul 15.
Efforts to accelerate Alzheimer's disease (AD) drug development have been spurred on by the creation of open science, public-private R&D consortia. An R&D consortium provides an improved structure for generating and disseminating AD knowledge across a range of organizations while also aligning their interests. Drawing from archival and interview data collected on 46 public-private R&D consortia focused wholly or in part on AD, we uncover two important innovations: the creation of novel consortium types that facilitate coordination beyond the individual consortium, and the practice of organizations joining multiple consortia. Collectively these innovations provide member organizations with different pathways for advancing AD research. These findings have significant implications for how member organizations should approach collaboration in the AD drug development process.
为了加速阿尔茨海默病(AD)药物的研发,开放科学和公私研发联盟应运而生。研发联盟为在一系列组织中生成和传播 AD 知识提供了一种改进的结构,同时也使他们的利益保持一致。我们从 46 个专注于 AD 的公私研发联盟的档案和访谈数据中发现了两个重要的创新:创建了新型的联盟类型,便于超越单个联盟进行协调,以及组织加入多个联盟的做法。这些创新为成员组织提供了不同的途径来推进 AD 研究。这些发现对成员组织在 AD 药物研发过程中应该如何合作具有重要意义。