Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Department of Anesthesiology and Pain Medicine, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Trends Pharmacol Sci. 2024 Oct;45(10):862-867. doi: 10.1016/j.tips.2024.06.005. Epub 2024 Jul 16.
Transient receptor potential melastatin (TRPM) channels have emerged as potential therapeutic targets for cerebral ischemia-reperfusion (I/R) injury. We highlight recent findings on the involvement of TRPM channels in oxidative stress, mitochondrial dysfunction, inflammation, and calcium overload. We also discuss the challenges and future directions in targeting TRPM channels for cerebral I/R injury.
瞬时受体电位 melastatin (TRPM) 通道已成为脑缺血再灌注 (I/R) 损伤的潜在治疗靶点。我们重点介绍了 TRPM 通道在氧化应激、线粒体功能障碍、炎症和钙超载中的作用的最新发现。我们还讨论了针对脑 I/R 损伤靶向 TRPM 通道的挑战和未来方向。
