Yuan Wenbin, Zhang Rui, Lyu Hao, Xiao Shuai, Guo Dong, Zhang Qi, Ali Declan William, Michalak Marek, Chen Xing-Zhen, Zhou Cefan, Tang Jingfeng
National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, School of Life and Health Sciences, Hubei University of Technology, Wuhan, China.
Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
Cell Death Discov. 2024 Jul 17;10(1):327. doi: 10.1038/s41420-024-02097-x.
tRNA is the RNA type that undergoes the most modifications among known RNA, and in recent years, tRNA methylation has emerged as a crucial process in regulating gene translation. Dysregulation of tRNA abundance occurs in cancer cells, along with increased expression and activity of tRNA methyltransferases to raise the level of tRNA modification and stability. This leads to hijacking of translation and synthesis of multiple proteins associated with tumor proliferation, metastasis, invasion, autophagy, chemotherapy resistance, and metabolic reprogramming. In this review, we provide an overview of current research on tRNA methylation in cancer to clarify its involvement in human malignancies and establish a theoretical framework for future therapeutic interventions targeting tRNA methylation processes.
转运RNA（tRNA）是已知RNA中经历修饰最多的RNA类型，近年来，tRNA甲基化已成为调节基因翻译的关键过程。癌细胞中会出现tRNA丰度失调，同时tRNA甲基转移酶的表达和活性增加，以提高tRNA修饰水平和稳定性。这导致翻译过程被劫持，并合成多种与肿瘤增殖、转移、侵袭、自噬、化疗耐药性和代谢重编程相关的蛋白质。在本综述中，我们概述了目前关于癌症中tRNA甲基化的研究，以阐明其在人类恶性肿瘤中的作用，并为未来针对tRNA甲基化过程的治疗干预建立理论框架。
