白细胞介素-6与接受初次切除的低级别胶质瘤患者癫痫控制不佳有关。
IL-6 is associated with poor seizure control in low-grade glioma patients undergoing primary resection.
作者信息
Zhang Qingyan, Tuerxun Nisagul, Tuerxun Shabier
机构信息
Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing 100191, China.
Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute of Beihang University, Hangzhou 310000, China.
出版信息
iScience. 2024 Jun 13;27(7):110267. doi: 10.1016/j.isci.2024.110267. eCollection 2024 Jul 19.
In this study, 198 patients with low-grade gliomas (LGGs) undergoing primary resection were evaluated for seizure status at 24 months after primary resection with the Engel classification of seizures, and 120 patients had good seizure control (class I) while 78 patients had poor seizure control (class II-IV). Multivariate analysis showed that cortex involvement, subtotal resection, serum IL-6 concentration, and neutrophil to lymphocyte ratio (NLR) were associated with poor seizure control. The area under curve (AUC) of serum IL-6 concentration, NLR and their combination applied in predicting poor seizure control was 0.756, 0.714, and 0.857, respectively. The AUC of combination prediction was significantly higher than those of individual prediction. Therefore, elevated serum IL-6 concentration was associated with poor seizure control in LLG patients undergoing primary resection and could be applied in predicting seizure control, and the predictive value could be elevated through adding other serum indices to IL-6.
在本研究中，对198例行初次切除的低级别胶质瘤（LGG）患者，采用恩格尔癫痫分级法评估初次切除术后24个月的癫痫状态，其中120例患者癫痫控制良好（I级），78例患者癫痫控制不佳（II - IV级）。多因素分析显示，皮质受累、次全切除、血清白细胞介素 - 6（IL - 6）浓度及中性粒细胞与淋巴细胞比值（NLR）与癫痫控制不佳相关。血清IL - 6浓度、NLR及其联合应用预测癫痫控制不佳的曲线下面积（AUC）分别为0.756、0.714和0.857。联合预测的AUC显著高于单项预测。因此，血清IL - 6浓度升高与行初次切除的LLG患者癫痫控制不佳相关，可用于预测癫痫控制情况，且通过将其他血清指标与IL - 6联合可提高预测价值。
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