Nath A Gowri, Dubey Prashant, Kumar Ankaj, Vaiphei Klaudi K, Rosenholm Jessica M, Bansal Kuldeep K, Gulbake Arvind
Department of Pharmaceutics National Institute of Pharmaceutical Education and Research, Guwahati, Assam 781101, India.
Pharmaceutical Sciences Laboratory Faculty of Science and Engineering Åbo Akademi University, Turku 20520, Finland.
J Lipids. 2024 Jul 10;2024:2683466. doi: 10.1155/2024/2683466. eCollection 2024.
Topical drug delivery employing drug nanocarriers has shown prominent results in treating topical ailments, especially those confined to the skin and eyes. Conventional topical formulations persist with drug and disease-related challenges during treatment. Various nanotechnology-driven approaches have been adopted to mitigate the issues associated with conventional formulations. Among these, cubosomes have shown potential applications owing to their liquid crystalline structure, which aids in bioadhesion, retention, sustained release, and loading hydrophilic and hydrophobic moieties. The phase transition behavior of glyceryl monooleate, the concentration of stabilizers, and critical packing parameters are crucial parameters that affect the formation of cubosomes. Microfluidics-based approaches constitute a recent advance in technologies for generating stable cubosomes. This review covers the recent topical applications of cubosomes for treating skin (psoriasis, skin cancer, cutaneous candidiasis, acne, and alopecia) and eye (fungal keratitis, glaucoma, conjunctivitis, and uveitis) diseases. The article summarizes the manufacturing and biological challenges (skin and ocular barriers) that must be considered and encountered for successful clinical outcomes. The patented products are successful examples of technological advancements within cosmeceuticals that support various topical applications with cubosomes in the pharmaceutical field.
采用药物纳米载体的局部给药在治疗局部疾病，特别是局限于皮肤和眼睛的疾病方面已显示出显著效果。传统的局部制剂在治疗过程中一直存在与药物和疾病相关的挑战。人们采用了各种纳米技术驱动的方法来缓解与传统制剂相关的问题。其中，立方液晶纳米粒由于其液晶结构而显示出潜在的应用前景，这种结构有助于生物粘附、滞留、缓释以及负载亲水和疏水部分。单油酸甘油酯的相变行为、稳定剂的浓度和临界堆积参数是影响立方液晶纳米粒形成的关键参数。基于微流控的方法是生成稳定立方液晶纳米粒技术的最新进展。这篇综述涵盖了立方液晶纳米粒最近在治疗皮肤疾病（银屑病、皮肤癌、皮肤念珠菌病、痤疮和脱发）和眼部疾病（真菌性角膜炎、青光眼、结膜炎和葡萄膜炎）方面的局部应用。文章总结了为获得成功的临床结果必须考虑和应对的制造和生物学挑战（皮肤和眼部屏障）。专利产品是药妆品技术进步的成功范例，支持了立方液晶纳米粒在制药领域的各种局部应用。
