Tsung Ta-Hsin, Chen Yi-Hao, Lu Da-Wen
Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Pharmaceutics. 2023 Feb 22;15(3):734. doi: 10.3390/pharmaceutics15030734.
The complex nature of the ocular drug delivery barrier presents a significant challenge to the effective administration of drugs, resulting in poor therapeutic outcomes. To address this issue, it is essential to investigate new drugs and alternative delivery routes and vehicles. One promising approach is the use of biodegradable formulations to develop potential ocular drug delivery technologies. These include hydrogels, biodegradable microneedles, implants, and polymeric nanocarriers such as liposomes, nanoparticles, nanosuspensions, nanomicelles, and nanoemulsions. The research in these areas is rapidly growing. In this review, we provide an overview of recent updates in biodegradable formulations for ocular drug delivery over the past decade. Additionally, we examine the clinical use of different biodegradable formulations in various ocular diseases. The aim of this review is to gain a deeper understanding of potential future trends in biodegradable ocular drug delivery systems and to raise awareness of their potential for practical clinical application as a means of providing new treatment options for ocular diseases.
眼部药物递送屏障的复杂性对药物的有效给药构成了重大挑战，导致治疗效果不佳。为了解决这个问题，研究新药以及替代递送途径和载体至关重要。一种有前景的方法是使用可生物降解制剂来开发潜在的眼部药物递送技术。这些技术包括水凝胶、可生物降解微针、植入物以及聚合物纳米载体，如脂质体、纳米颗粒、纳米混悬液、纳米胶束和纳米乳剂。这些领域的研究正在迅速发展。在这篇综述中，我们概述了过去十年中用于眼部药物递送的可生物降解制剂的最新进展。此外，我们研究了不同可生物降解制剂在各种眼部疾病中的临床应用。这篇综述的目的是更深入地了解可生物降解眼部药物递送系统未来的潜在趋势，并提高人们对其作为为眼部疾病提供新治疗选择的实际临床应用潜力的认识。
