Duduyemi Babatunde Moses, Kwakye Thelma, Sallah Lorraine
Department of Pathology, University of Sierra Leone Teaching Hospitals Complex, Sierra Leone.
Department of Physiology, Kwame Nkrumah University of Science and Technology, Ghana.
Niger Med J. 2024 Jun 20;65(3):354-366. doi: 10.60787/nmj-v65i3-429. eCollection 2024 May-Jun.
Breast cancer has produced more lost disability-adjusted life years (DALYs) than any other type of cancer. The prevalence of the disease, especially triple negative breast cancer (TNBC) in Africa is on the rise, with poor survival rates. With the great advancements in treatments of breast cancers, that of TNBC is still a challenge due to its narrowed treatment options and poor disease prognosis. This research seeks to explore the expression of kaiso in Ghanaian breast cancer and how they may modulate clinicopathological features, and disease prognosis.
A cross-sectional retrospective study was conducted on formalin-fixed paraffin-embedded (FFPE) breast cancer tissues retrieved from the archives of the pathology unit of Komfo Anokye Teaching Hospital (KATH). Immunohistochemistry assessment was performed on haematoxylin and eosin-stained slides selected for tissue microarray construction. Data were analysed using SPSS version 28 and Microsoft excel 2013.
55.3% of the cases tested negative to progesterone receptor (PR), oestrogen receptor (ER), and human epidermal growth receptor 2 (HER2). There were significant associations between menopausal status and molecular subtype (p=0.010), Kaiso expression and histological diagnoses (<0.001) and Kaiso against lymphovascular invasion (0.050). However, there were no significant associations between Kaiso localization and the clinicopathological features although 63.9% of the expression was seen in the nucleus.
The study indicates that Kaiso is highly expressed in Ghanaian TNBC and likely associated with worse outcomes in aggressive tumour types.
乳腺癌导致的伤残调整生命年损失比其他任何类型的癌症都多。该疾病的患病率，尤其是非洲的三阴性乳腺癌（TNBC）呈上升趋势，生存率较低。随着乳腺癌治疗取得巨大进展，TNBC的治疗仍然是一项挑战，因为其治疗选择有限且疾病预后较差。本研究旨在探讨Kaiso在加纳乳腺癌中的表达及其对临床病理特征和疾病预后的调节作用。
对从科姆福·阿诺克耶教学医院（KATH）病理科档案中检索到的福尔马林固定石蜡包埋（FFPE）乳腺癌组织进行横断面回顾性研究。对选择用于组织芯片构建的苏木精和伊红染色玻片进行免疫组织化学评估。使用SPSS 28版和Microsoft Excel 2013对数据进行分析。
55.3%的病例对孕激素受体（PR）、雌激素受体（ER）和人表皮生长因子受体2（HER2）检测呈阴性。绝经状态与分子亚型之间存在显著关联（p = 0.010），Kaiso表达与组织学诊断之间存在显著关联（<0.001），Kaiso与淋巴管浸润之间存在显著关联（0.050）。然而，尽管63.9%的表达见于细胞核，但Kaiso定位与临床病理特征之间无显著关联。
该研究表明，Kaiso在加纳TNBC中高表达，可能与侵袭性肿瘤类型的较差预后相关。
