Liu Jing, Si Jingmei, Zhao Weiwei
Department of Physical Education, Lyuliang University, Lv Liang, Shan, China.
Luliang People's Hospital, Lv Liang, Shan, China.
Exp Aging Res. 2025 May-Jun;51(3):331-349. doi: 10.1080/0361073X.2024.2377427. Epub 2024 Jul 18.
To observe the effects of Tai Chi training on depression symptoms and serum kynurenine metabolites in perimenopausal women and explore the mechanism of Tai Chi training in anti-depression.
A total of 72 perimenopausal women with depression were randomly selected from Lishi District and divided into a Tai Chi training group (36 cases) and a control group (36 cases). At the same time, 36 perimenopausal healthy women were randomly selected as the normal group. The Tai Chi training group was intervened with 24 simplified Tai Chi exercises, and the depression self-rating scale was used to evaluate the depression status. The levels of tryptophan (Trp) and kynurenine (KYN) metabolites in serum were determined by high-performance liquid chromatography-ultraviolet detection.
Before the experiment, compared with the normal healthy group, the depression self-rating scale scores, serum KYN and quinolinic acid (QUIN) levels, and KYN/Trp ratio of the control group and Tai Chi group were significantly increased ( < .01), and the serum kynurenic acid (KYNA) level was significantly decreased ( < .01). After the experiment, compared with the normal healthy group, the depression self-rating scale scores of the Tai Chi group were significantly decreased ( < .01), the serum KYNA content was increased ( < .01), the serum KYN and QUIN contents were significantly decreased ( < .01), and the KYN/Trp ratio was significantly decreased ( < .01).
Tai Chi training can significantly improve depression symptoms in perimenopausal women. The mechanism of Tai Chi training in improving depression symptoms in perimenopausal women may be achieved by regulating abnormal kynurenine metabolism.
观察太极拳训练对围绝经期女性抑郁症状及血清犬尿氨酸代谢产物的影响，探讨太极拳训练抗抑郁的机制。
从离石区随机选取72例围绝经期抑郁女性，分为太极拳训练组（36例）和对照组（36例）。同时，随机选取36例围绝经期健康女性作为正常组。太极拳训练组进行24式简化太极拳练习，采用抑郁自评量表评估抑郁状态。采用高效液相色谱-紫外检测法测定血清中色氨酸（Trp）和犬尿氨酸（KYN）代谢产物水平。
实验前，与正常健康组相比，对照组和太极拳组的抑郁自评量表评分、血清KYN和喹啉酸（QUIN）水平以及KYN/Trp比值均显著升高（<0.01），血清犬尿喹啉酸（KYNA）水平显著降低（<0.01）。实验后，与正常健康组相比，太极拳组的抑郁自评量表评分显著降低（<0.01），血清KYNA含量升高（<0.01），血清KYN和QUIN含量显著降低（<0.01），KYN/Trp比值显著降低（<0.01）。
太极拳训练可显著改善围绝经期女性的抑郁症状。太极拳训练改善围绝经期女性抑郁症状的机制可能是通过调节异常的犬尿氨酸代谢实现的。
