Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia; Orygen, Parkville, Victoria, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia; Neuropsychiatry Centre, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Psychiatry Res. 2024 Sep;339:116073. doi: 10.1016/j.psychres.2024.116073. Epub 2024 Jul 4.
Accelerated brain ageing has been observed in multiple psychiatric disorders. This study examined whether relationships between age and plasma neurofilament light (NfL) protein differed in individuals with psychiatric disorders (major depressive disorder (n = 42), bipolar affective disorder (n = 121), treatment-resistant schizophrenia (TRS, n = 82)) compared to two healthy control (HC) groups (n = 1,926 and n = 59). Compared to two independent HC samples, individuals with TRS demonstrated a stronger positive relationship between age and NfL levels. Individuals with BPAD had a stronger negative relationship between age and NfL levels compared to the large normative HC cohort, but not locally-acquired HCs. These findings show that plasma NfL levels are differentially associated with age in individuals with TRS and BPAD compared to healthy individuals.
在多种精神疾病中都观察到了大脑加速老化。本研究考察了在患有精神疾病的个体（重度抑郁症（n = 42）、双相情感障碍（n = 121）、治疗抵抗性精神分裂症（TRS，n = 82））中，年龄与血浆神经丝轻链（NfL）蛋白之间的关系是否与两个健康对照组（n = 1926 和 n = 59）不同。与两个独立的 HC 样本相比，TRS 个体的年龄与 NfL 水平之间呈更强的正相关关系。与大的正态 HC 队列相比，BPAD 个体的年龄与 NfL 水平之间呈更强的负相关关系，但与本地获得的 HC 个体则没有。这些发现表明，与健康个体相比，TRS 和 BPAD 个体的血浆 NfL 水平与年龄的相关性存在差异。
