Pan Yuke, Wang Youyi, Xu Meinian, Zhong Meizhen, Peng Xiaoming, Zeng Kang, Huang Xiaowen
The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou, China,
J Innate Immun. 2024;16(1):385-396. doi: 10.1159/000539534. Epub 2024 Jul 18.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by recurrent eczematous lesions and severe pruritus. The economic burden and time penalty caused by the relapse of AD reduce patients' life quality.
AD has complex pathogenesis, including genetic disorders, epidermal barrier dysfunction, abnormal immune responses, microbial dysbiosis of the skin, and environmental factors. Recently, the role of innate immune cells in AD has attracted considerable attention. This review highlighted recent findings on innate immune cells in the onset and progression of AD.
Innate immune cells play essential roles in the pathogenesis of AD and enough attention should be given for treating AD from the perspective of innate immunity in clinics.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为反复发作的湿疹样皮损和严重瘙痒。AD复发所导致的经济负担和时间损失会降低患者的生活质量。
AD具有复杂的发病机制，包括遗传紊乱、表皮屏障功能障碍、免疫反应异常、皮肤微生物群失调以及环境因素。最近，固有免疫细胞在AD中的作用引起了相当大的关注。本综述重点介绍了关于固有免疫细胞在AD发病和进展中的最新研究结果。
固有免疫细胞在AD发病机制中起重要作用，临床治疗AD时应从固有免疫角度给予足够重视。
