Ornelas Isis M, Carrilho Beatriz de S, Ventura Matheus Antonio V de C, Domith Ivan, de V Silveira Christiane M, Dos Santos Vanessa F, Delou João M, Moll Francisco, Pereira Henrique Marcelo G, Junqueira Magno, Aguilaniu Hugo, Rehen Stevens
Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro 22281-100, Brazil.
Programa de Pós-graduação em Ciências Morfológicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.
Neurosci Lett. 2024 Aug 10;837:137903. doi: 10.1016/j.neulet.2024.137903. Epub 2024 Jul 20.
Lysergic acid diethylamide (LSD) is a synthetic psychedelic compound with potential therapeutic value for psychiatric disorders. This study aims to establish Caenorhabditis elegans as an in vivo model for examining LSD's effects on locomotor behavior. Our results demonstrate that LSD is absorbed by C. elegans and that the acute treatment reduces animal speed, similar to the role of endogenous serotonin. This response is mediated in part by the serotonergic receptors SER-1 and SER-4. Our findings highlight the potential of this nematode as a new experimental model in psychedelic research.
麦角酸二乙酰胺（LSD）是一种合成的致幻化合物，对精神疾病具有潜在的治疗价值。本研究旨在建立秀丽隐杆线虫作为体内模型，以研究LSD对运动行为的影响。我们的结果表明，秀丽隐杆线虫能够吸收LSD，并且急性处理会降低动物的运动速度，这与内源性血清素的作用类似。这种反应部分由血清素能受体SER-1和SER-4介导。我们的研究结果突出了这种线虫作为致幻剂研究新实验模型的潜力。
