Department of Physiology, Gujranwala Medical College, Gujranwala, Pakistan.
Department of Physiology, University of Health Sciences, Lahore, Pakistan.
J Pak Med Assoc. 2024 Jul;74(7):1338-1341. doi: 10.47391/JPMA.10405.
The current study was planned to compare serum levels of secreted frizzled related protein-4, insulin resistance and waist-to-height ratio in individuals with and without a diabetic background, and to assess the correlation of these markers with family history of diabetes. The cross-sectional comparative study comprised 80 subjects with confirmed normal glucose tolerance values. Parameters assessed included secreted frizzled related protein-4, fasting glucose, random glucose, fasting insulin, homeostasis model of assessment of insulin resistance and waist-toheight ratio values. Those without a diabetic background had significantly higher frizzled related protein-4 levels (p=0.02). Although subjects with family history of diabetes showed higher mean fasting glucose, waist circumference and waist-to-height ratio, these differences were not statistically significant (p>0.05). However, there was a strong positive correlation with waist circumference, waistto- height ratio, fasting insulin and homeostasis model of assessment of insulin resistance (p=0.0001). There was no significant correlation of diabetic background with frizzled related protein-4 SFRP-4, homeostasis model of assessment of insulin resistance and waist-to-height ratio (p>0.05).
本研究旨在比较有和无糖尿病背景个体的血清分泌卷曲相关蛋白-4（SFRP-4）水平、胰岛素抵抗和腰高比，并评估这些标志物与糖尿病家族史的相关性。这项横断面对比研究纳入了 80 名血糖正常的受试者。评估的参数包括 SFRP-4、空腹血糖、随机血糖、空腹胰岛素、胰岛素抵抗评估的稳态模型以及腰高比。无糖尿病背景的受试者 SFRP-4 水平显著更高（p=0.02）。尽管有糖尿病家族史的受试者空腹血糖、腰围和腰高比均值较高，但这些差异无统计学意义（p>0.05）。然而，它们与腰围、腰高比、空腹胰岛素和胰岛素抵抗评估的稳态模型呈强正相关（p=0.0001）。糖尿病背景与 SFRP-4、胰岛素抵抗评估的稳态模型和腰高比无显著相关性（p>0.05）。
