脾切除术后中性粒细胞激活缺陷。
Defective activation of neutrophils after splenectomy.
作者信息
Foster P N, Bolton R P, Cotter K L, Losowsky M S
出版信息
J Clin Pathol. 1985 Oct;38(10):1175-8. doi: 10.1136/jcp.38.10.1175.
Neutrophil chemotaxis and phagocytosis in the presence of serum from 20 patients who had undergone splenectomy and from 15 healthy volunteers was studied. The mean distance migrated by normal neutrophils in the presence of serum from the patients after splenectomy was significantly less than that when normal serum was used (p less than 0.005). The percentage of neutrophils phagocytosing a yeast was also significantly reduced in the presence of serum from patients after splenectomy (p less than 0.02). In addition, when neutrophils from these patients were studied both chemotaxis and phagocytosis were enhanced in normal compared with autologous serum (p less than 0.05).
对20例接受脾切除术患者及15名健康志愿者的血清存在情况下的中性粒细胞趋化性和吞噬作用进行了研究。在脾切除术后患者血清存在情况下，正常中性粒细胞迁移的平均距离显著小于使用正常血清时（p<0.005）。在脾切除术后患者血清存在情况下，吞噬酵母的中性粒细胞百分比也显著降低（p<0.02）。此外，当研究这些患者的中性粒细胞时，与自体血清相比，在正常血清中趋化性和吞噬作用均增强（p<0.05）。
Zotero 插件