Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Department of Ultrasound, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Ultrasound Med Biol. 2024 Oct;50(10):1544-1550. doi: 10.1016/j.ultrasmedbio.2024.06.007. Epub 2024 Jul 18.
The study aimed to determine the influencing factors, reference range, the changes of salivary gland secretion function and repeatability of measurements taken from ultrasound (US) viscoelastic imaging in the salivary glands of healthy adults.
From August 2023 to October 2023, 206 healthy adults were recruited. In November 2023, 50 healthy adults were recruited for acid stimulation testing. All volunteers underwent conventional and viscoelastic US of the salivary glands. The viscoelasticity values in different regions of interest (ROI), observers, genders, ages, body mass index (BMI) groups and before and after acid stimulation were compared separately. A two-sided 95% reference range was estimated accordingly.
There was no difference in the E-mean and V-mean values among different ROIs (p > 0.05). The intra-group correlation coefficient values between the different observers were all >0.908. Except for the influence of age on the E-mean value of the parotid gland, the V-mean of the parotid gland, the E-mean and V-mean of the submandibular gland were not affected by age, gender or BMI. Finally, differences were detected in the E-means and V-means of the parotid and submandibular glands before and after acid stimulation (p < 0.05).
US viscoelastic imaging is a simple and reliable technique for evaluating the stiffness and viscosity of salivary glands in healthy adults. It also can be used to dynamically evaluate the changes of salivary gland secretion function.
本研究旨在确定健康成年人唾液腺超声（US）黏弹成像中唾液腺分泌功能的影响因素、参考范围、变化及测量的重复性。
2023 年 8 月至 10 月，招募了 206 名健康成年人。2023 年 11 月，招募了 50 名健康成年人进行酸刺激试验。所有志愿者均接受唾液腺常规和黏弹 US 检查。分别比较了不同感兴趣区（ROI）、观察者、性别、年龄、体质量指数（BMI）组以及酸刺激前后的黏弹性值。相应地，估计了双侧 95%参考范围。
不同 ROI 之间的 E-mean 和 V-mean 值没有差异（p>0.05）。不同观察者之间的组内相关系数值均>0.908。除年龄对腮腺 E-mean 值和腮腺 V-mean 值、下颌下腺 E-mean 值和 V-mean 值的影响外，年龄、性别或 BMI 均不影响腮腺和下颌下腺的 E-mean 值和 V-mean 值。最后，酸刺激前后腮腺和下颌下腺的 E-mean 值和 V-mean 值存在差异（p<0.05）。
US 黏弹成像技术是一种简单可靠的方法，可用于评估健康成年人唾液腺的硬度和黏度，也可用于动态评估唾液腺分泌功能的变化。
