Department of Dermatology, Poznań University of Medical Sciences, Poznań, Poland.
Department of Urology, Poznań University of Medical Sciences, Poznań, Poland.
Skin Res Technol. 2024 Jul;30(7):e13851. doi: 10.1111/srt.13851.
Although non-invasive diagnostic methods are widely used to examine the nail apparatus (NA), studies in healthy ones are scarce, and analyzes were often conducted in small groups. In the literature, there are only a few reports on TOWL measurements. The results of TEWL studies in the proximal nailfold have not been published so far.
Based on a detailed interview and physical examination, 81 volunteers (40 women and 41 men) aged from 22 to 65 years were qualified for the study. In this study, the overall examination of the NA in relation to water loss was performed for the first time, regarding the hand (d, dominant; n, non-dominant) and finger types (number, start of count from thumbs) as well as sex and age.
The average TEWL value in the entire group ranged from 7.53 c.u. in the finger nd4 to 11.09 c.u. in nd1. Both in the dominant and non-dominant hand, in the entire analyzed group, and taking into account gender, weak statistically significant relationships were observed between the finger type value and TEWL (p < 0.05).The TEWL values were lower moving away from the thumb, The average TOWL value in the entire group ranged from 5.01 c.u. in d1 to 7.34 c.u. in d5. Both in the dominant and non-dominant hand, in the entire analyzed group and considering gender, statistically significant relationships were observed between the type of finger and TOWL values (p < 0.05). The TOWL values were higher moving away from the thumb. Subsequently, the values of TOWL and TEWL did not depend on type of hand (dominant or non-dominant), sex and age. Weak and moderate statistically significant correlations were found between TEWL and TOWL values in the entire study group and in females, as well as in selected fingers in males (d2, nd2, d3, nd3, d5, nd5) (p < 0.05, r < 0.27).
Non-invasive diagnostics such TEWL and TOWL measurements are useful to assess differences in structure and function between types of fingers. However, obtained results demand further studies.
尽管非侵入性诊断方法广泛用于检查指甲装置（NA），但在健康人群中的研究很少，而且分析通常在小群体中进行。在文献中，只有少数关于 TOWL 测量的报告。迄今为止，近端甲襞 TEWL 研究的结果尚未公布。
基于详细的访谈和体检，有 81 名志愿者（40 名女性和 41 名男性）年龄在 22 至 65 岁之间，符合研究条件。在这项研究中，首次对与水分流失有关的 NA 进行了全面检查，涉及手（d，优势；n，非优势）和手指类型（数量，从拇指开始计数）以及性别和年龄。
整个组的平均 TEWL 值范围从手指 nd4 的 7.53 c.u.到 nd1 的 11.09 c.u.。在优势手和非优势手中，在整个分析组中，考虑到性别，观察到手指类型值与 TEWL 之间存在微弱的统计学显著关系（p < 0.05）。TEWL 值从拇指开始逐渐降低。整个组的平均 TOWL 值范围从 d1 的 5.01 c.u.到 d5 的 7.34 c.u.。在优势手和非优势手中，在整个分析组中，考虑到性别，观察到手指类型与 TOWL 值之间存在统计学显著关系（p < 0.05）。TOWL 值从拇指开始逐渐升高。随后，TOWL 和 TEWL 值不取决于手的类型（优势或非优势）、性别和年龄。在整个研究组以及女性中，以及在男性的某些手指中（d2、nd2、d3、nd3、d5、nd5），发现 TEWL 和 TOWL 值之间存在微弱和中度统计学显著相关性（p < 0.05，r < 0.27）。
非侵入性诊断如 TEWL 和 TOWL 测量可用于评估手指类型之间的结构和功能差异。然而，获得的结果需要进一步研究。
Zotero 插件