Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.
Otolaryngol Head Neck Surg. 2024 Oct;171(4):1092-1096. doi: 10.1002/ohn.851. Epub 2024 Jun 21.
The objective of this study was to describe risk factors and recurrence patterns that can guide the creation of evidence-based surveillance guidelines for advanced cutaneous squamous cell carcinoma of the head and neck.
This was a single-institution retrospective case series.
High-volume academic head and neck surgical oncology practice.
Patients who underwent surgery for cutaneous squamous cell carcinoma of the head and neck staged Brigham and Women's Hospital T2b and T3 from 2003 to 2023 were reviewed. Patient demographics, clinicopathologic history, cancer data, treatment, and outcomes were abstracted. Disease-free survival and risk factors for recurrence were described.
A total of 183 patients were included. Fifty-six (30.6%) experienced recurrence. This included local recurrence in 21 (11.5%), regional in 21 (13.3%), and distant in 11 (6%). The majority of regional and distant recurrences occurred within 1 year of surgery.
The majority of disease recurrence occurs in the first 1 to 2 years following surgical excision of advanced-stage cutaneous squamous cell carcinoma of the head and neck. Close surveillance and frequent imaging within those years are critical to catch subclinical and distant diseases.
本研究旨在描述风险因素和复发模式，以指导制定针对头颈部晚期皮肤鳞状细胞癌的循证监测指南。
这是一项单机构回顾性病例系列研究。
高容量的学术头颈部肿瘤外科实践。
回顾了 2003 年至 2023 年间在布莱根妇女医院接受 T2b 和 T3 期头颈部皮肤鳞状细胞癌手术的患者。提取患者人口统计学、临床病理病史、癌症数据、治疗和结局。描述无病生存率和复发的危险因素。
共纳入 183 例患者。56 例（30.6%）出现复发。包括局部复发 21 例（11.5%），区域复发 21 例（13.3%），远处转移 11 例（6%）。大多数区域和远处复发发生在手术切除后的 1 至 2 年内。
头颈部晚期皮肤鳞状细胞癌切除后，大多数疾病复发发生在术后 1 至 2 年内。在这些年内进行密切监测和频繁的影像学检查对于发现亚临床和远处疾病至关重要。
