Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China.
Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China; Department of Biochemistry, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt.
Microbiol Res. 2024 Oct;287:127835. doi: 10.1016/j.micres.2024.127835. Epub 2024 Jul 17.
Lignin, a significant byproduct of the paper and pulp industry, is attracting interest due to its potential utilization in biomaterial-based sectors and biofuel production. Investigating biological methods for converting lignin into valuable products is crucial for effective utilization and has recently gained growing attention. Several microorganisms effectively decomposed low molecular weight lignins, transforming them into intermediate compounds via upper and lower metabolic pathways. This review focuses on assessing bacterial metabolic pathways involved in the breakdown of lignin into aromatic compounds and their subsequent utilization by different bacteria through various metabolic pathways. Understanding these pathways is essential for developing efficient synthetic metabolic systems to valorize lignin and obtain valuable industrial aromatic chemicals. The concept of "biological funneling," which involves examining key enzymes, their interactions, and the complex metabolic pathways associated with lignin conversion, is crucial in lignin valorization. By manipulating lignin metabolic pathways and utilizing biological routes, many aromatic compounds can be synthesized within cellular factories. Although there is insufficient evidence regarding the complete metabolism of polyaromatic hydrocarbons by particular microorganisms, understanding lignin-degrading enzymes, regulatory mechanisms, and interactions among various enzyme systems is essential for optimizing lignin valorization. This review highlights recent advancements in lignin valorization, bio-funneling, multi-omics, and analytical characterization approaches for aromatic utilization. It provides up-to-date information and insights into the latest research findings and technological innovations. The review offers valuable insights into the future potential of biological routes for lignin valorization.
木质素是造纸和纸浆工业的重要副产品，由于其在生物基材料和生物燃料生产领域的潜在应用而受到关注。研究将木质素转化为有价值产品的生物方法对于有效利用木质素至关重要，近年来越来越受到关注。一些微生物有效地分解低分子量木质素，通过上下代谢途径将其转化为中间化合物。本综述重点评估了细菌代谢途径在木质素分解为芳香族化合物及其随后通过不同代谢途径被不同细菌利用中的作用。了解这些途径对于开发有效的合成代谢系统以实现木质素的增值和获得有价值的工业芳香族化学品至关重要。“生物漏斗”的概念涉及到关键酶的检查、它们的相互作用以及与木质素转化相关的复杂代谢途径，这在木质素增值中非常重要。通过操纵木质素代谢途径和利用生物途径，可以在细胞工厂中合成许多芳香族化合物。尽管关于特定微生物对多环芳烃的完全代谢的证据不足，但了解木质素降解酶、调控机制以及各种酶系统之间的相互作用对于优化木质素增值至关重要。本综述重点介绍了木质素增值、生物漏斗、多组学和芳香族利用的分析表征方法的最新进展。它提供了有关最新研究发现和技术创新的最新信息和见解。该综述为生物途径在木质素增值方面的未来潜力提供了有价值的见解。
