Masaoka T
Gan No Rinsho. 1985 Jul;31(9 Suppl):1019-23.
Recently marked progress in many fields around the treatment of acute leukemia has resulted a marked improvement in the therapeutic results. Establishment of fundamental principles of therapy, i.e., understanding of remission induction, consolidation and maintenance has supported a systemic analysis of treatment. New antileukemia drugs such as Aclacinomycin, THP-adriamycin, Epirubicin, Mitoxantrone, Vindesine, Etoposide, PL-AC together with the immunotherapeutic agent i.e., Bestatin, kurestin and Nocardia-CWS were studied and found to show their merits in the treatment. Monitoring the patients by 5000 leukocyte differential or the development of new antibiotics or improvement of laminar air flow rooms etc, has supported the antileukemic therapy. Bone marrow transplantation, allogeneic, syngeneic or autologous, has shown a very rapid progress and is proved to be a reliable treatment with very high rate of complete cure.
近年来,急性白血病治疗的多个领域取得了显著进展,治疗效果有了明显改善。治疗基本原则的建立,即对缓解诱导、巩固和维持的理解,为治疗的系统分析提供了支持。研究了新的抗白血病药物,如阿克拉霉素、吡柔比星、表柔比星、米托蒽醌、长春地辛、依托泊苷、PL - AC,以及免疫治疗药物,如贝司他汀、库瑞汀和诺卡氏菌细胞壁骨架(Nocardia - CWS),发现它们在治疗中各有优点。通过5000白细胞分类计数监测患者、开发新抗生素或改善层流洁净室等,为抗白血病治疗提供了支持。同种异体、同基因或自体骨髓移植取得了非常迅速的进展,被证明是一种可靠的治疗方法,完全治愈率很高。