Department of Orthopaedics, Lanzhou University Second Hospital, Lanzhou, P.R. China.
J Orthop Surg (Hong Kong). 2024 May-Aug;32(2):10225536241266703. doi: 10.1177/10225536241266703.
Mycobacterium tuberculosis infection has emerged as a global public health issue, predominantly manifesting as pulmonary tuberculosis. Bone and joint tuberculosis, with spinal tuberculosis accounting for approximately 50%, represents a significant form of extrapulmonary tuberculosis. Over the past years, there has been a rise in the incidence of spinal tuberculosis, and research concerning this area has gained significant attention. At present, animal models provide a means to investigate the pathogenesis, drug resistance, and novel treatment approaches for spinal tuberculosis. New Zealand rabbits, possessing a comparable anatomical structure to humans and capable of reproducing typical pathological features of human tuberculosis, are extensively employed in spinal tuberculosis research using animal models. This article comprehensively evaluates the strengths, considerations in strain selection, various modelling approaches, and practical applications of the rabbit model in studying spinal tuberculosis based on pertinent literature to guide fundamental research in this field by providing valuable insights into appropriate animal model selection.
结核分枝杆菌感染已成为全球公共卫生问题，主要表现为肺结核。骨关节结核中约 50%为脊柱结核，是一种重要的肺外结核形式。近年来，脊柱结核的发病率呈上升趋势，该领域的研究受到了广泛关注。目前，动物模型为研究脊柱结核的发病机制、耐药性和新的治疗方法提供了手段。新西兰兔具有与人相似的解剖结构，能够再现人类结核病的典型病理特征，因此被广泛应用于脊柱结核的动物模型研究。本文综合评价了兔模型在研究脊柱结核方面的优势、品系选择的注意事项、各种建模方法以及实际应用，通过相关文献为该领域的基础研究提供了有价值的见解，指导了合适动物模型的选择。
