Brunner G, Lösgen H
Leber Magen Darm. 1985 Sep;15(5):186-91.
Many techniques have been developed to support liver function in patients with hepatic failure. Only two of these methods are suited to be used in adequately equipped hospitals under appropriate safety conditions. Exchange of toxin-rich patient plasma against fresh frozen plasma will decrease plasma toxin levels and substitute coagulation factors and proteins. This procedure however should be used in intervals of at least 3-4 days because more frequent application will lead to lung or cerebral complications. Dialysis and hemofiltration will remove water soluble toxins from patient blood as well as excess amino acids which are considered to be precursors of toxic lipophilic metabolites. Addition of certain amino acids to dialysis fluid in physiological concentrations will help to avoid loss of essential amino acids (with approx. normal plasma concentration). In a very few special centers treatment by liver perfusion of human or pavian livers, or by liver transplantation can be performed.
已经开发出许多技术来支持肝功能衰竭患者的肝功能。在适当的安全条件下，只有其中两种方法适合在设备齐全的医院中使用。用新鲜冰冻血浆置换富含毒素的患者血浆将降低血浆毒素水平，并替代凝血因子和蛋白质。然而，此程序应至少间隔3 - 4天使用，因为更频繁的应用会导致肺部或脑部并发症。透析和血液滤过将从患者血液中去除水溶性毒素以及过量的氨基酸，这些氨基酸被认为是有毒亲脂性代谢物的前体。在透析液中添加生理浓度的某些氨基酸将有助于避免必需氨基酸的流失（血浆浓度约正常）。在极少数特殊中心，可以进行人或禽类肝脏的肝灌注治疗或肝移植。
