评估听觉神经病谱系障碍儿童耳蜗神经对电刺激的神经同步性。
Assessing Neural Synchrony in the Cochlear Nerve to Electrical Stimulation in Children With Auditory Neuropathy Spectrum Disorder.
作者信息
He Shuman, Chao Xiuhua, Yuan Yi, Skidmore Jeffrey, Uhler Kristin M
机构信息
Department of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, Ohio, USA.
Department of Otolaryngology-Head and Neck Surgery, Shandong Provincial ENT Hospital, Shandong University, Jinan, China.
出版信息
Ear Hear. 2024 Jul 22. doi: 10.1097/AUD.0000000000001567.
OBJECTIVES
This study reported phase locking values (PLVs) that quantified the trial-to-trial phase coherence of electrically evoked compound action potentials in children with auditory neuropathy spectrum disorders (ANSD) and children with Gap Junction Beta 2 (GJB2) mutations, a patient population without noticeable cochlear nerve damage.
DESIGN
PLVs were measured at three electrode locations in 11 children with ANSD and 11 children with GJB2 mutations. Smaller PLVs indicated poorer neural synchrony. A linear mixed-effects model was used to compare PLVs measured at different electrode locations between participant groups.
RESULTS
After controlling for the stimulation level effect, children with ANSD had smaller PLVs than children with GJB2 mutations at all three electrode locations.
CONCLUSIONS
Cochlear-implanted children with ANSD show poorer peripheral neural synchrony than children with GJB2 mutations.
目的
本研究报告了锁相值（PLV），该值量化了听觉神经病谱系障碍（ANSD）儿童和缝隙连接蛋白β2（GJB2）突变儿童（这一没有明显耳蜗神经损伤的患者群体）中电诱发复合动作电位的逐次试验相位相干性。
设计
在11名ANSD儿童和11名GJB2突变儿童的三个电极位置测量PLV。较小的PLV表明神经同步性较差。使用线性混合效应模型比较参与者组在不同电极位置测量的PLV。
结果
在控制刺激水平效应后，ANSD儿童在所有三个电极位置的PLV均小于GJB2突变儿童。
结论
植入人工耳蜗的ANSD儿童比GJB2突变儿童表现出更差的外周神经同步性。
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