He Shuman, Bruce Ian C, Gao Zi, Aiello Ross A, Mueller Christopher R
Department of Otolaryngology - Head and Neck Surgery, The Ohio State University, 915 Olentangy River Road, Columbus, OH 43212.
Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, L8S 4K1, Canada.
medRxiv. 2025 May 3:2025.05.01.25326811. doi: 10.1101/2025.05.01.25326811.
The goal of this study was to evaluate the use of interpeak latency (IPL) and its inter-trial variability (VIL) of the electrically evoked compound action potential as potential alternative indicators to the phase locking value (PLV) metric that has previously been used to quantify neural synchrony in the cochlear nerve (CN) of cochlear implant (CI) users.
IPLs were compared among children with auditory neuropathy spectrum disorder, cochlear nerve deficiency, or typical sensorineural hearing loss, and postlingually deafened adult CI users. The VIL was assessed only in adults. Their associations with gap detection thresholds (GDT), speech perception scores, and PLVs were examined.
The VIL, but not the IPL, was correlated with GDT, speech perception outcomes, and the PLV. Group, age and electrode location effects on the IPL could not be explained solely by neural synchrony.
The VIL, but not the IPL, is indicative of neural synchrony in the CN. Similar to the PLV, the VIL is affected by the CI's sampling rate and internal noise.
本研究的目的是评估电诱发复合动作电位的峰间潜伏期（IPL）及其试验间变异性（VIL）作为潜在替代指标的用途，此前曾使用锁相值（PLV）指标来量化人工耳蜗（CI）使用者的蜗神经（CN）中的神经同步性。
比较了患有听觉神经病谱系障碍、蜗神经缺损或典型感音神经性听力损失的儿童以及语后聋成年CI使用者的IPL。仅在成年人中评估了VIL。检查了它们与间隙检测阈值（GDT）、言语感知分数和PLV的关联。
VIL而非IPL与GDT、言语感知结果和PLV相关。IPL的组、年龄和电极位置效应不能仅由神经同步来解释。
VIL而非IPL可指示CN中的神经同步性。与PLV类似，VIL受CI的采样率和内部噪声影响。
