Soutome Yuta, Sugiu Kenji, Hiramatsu Masafumi, Haruma Jun, Ebisudani Yuki, Kimura Ryo, Edaki Hisanori, Kawakami Masato, Fujita Juntaro, Tanaka Shota
Department of Neurological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences.
No Shinkei Geka. 2024 Jul;52(4):794-804. doi: 10.11477/mf.1436204978.
Preoperative embolization(POE)of intracranial meningioma is performed worldwide. Although clear evidence of the effectiveness of POE has not been reported in the literature, the technique plays an important role in open surgery, especially for large or skull base meningiomas. The purposes of embolization include: 1)induction of tumor necrosis, resulting in a safer operation, 2)reduction in intraoperative bleeding, and 3)decrease in operative time. Knowledge of the functional vascular anatomy, embolic materials, and endovascular techniques is paramount to ensure safe embolization. Our standard procedure is as follows: 1)embolization is performed several days before open surgery; 2)in cases with strong peritumoral edema, steroid administration or embolization may be performed immediately prior to surgery; 3)patients undergo the procedure under local anesthesia; 4)the microcatheter is inserted as close as possible to the tumor; 5)particulate emboli are the first-line material; 6)embolization is occasionally performed with N-butyl cyanoacrylate(NBCA)glue; and 7)if possible, additional proximal feeder occlusion with coils is performed. The JR-NET study previous showed the situation regarding intracranial tumor embolization in Japan. Endovascular neurosurgeons should fully discuss the indications and strategies for POE with tumor neurosurgeons to ensure safe and effective procedures.
颅内脑膜瘤的术前栓塞(POE)在全球范围内均有开展。尽管文献中尚未报道POE有效性的确切证据,但该技术在开放手术中发挥着重要作用,尤其是对于大型或颅底脑膜瘤。栓塞的目的包括:1)诱导肿瘤坏死,从而使手术更安全;2)减少术中出血;3)缩短手术时间。了解功能性血管解剖结构、栓塞材料和血管内技术对于确保安全栓塞至关重要。我们的标准操作流程如下:1)在开放手术前几天进行栓塞;2)对于瘤周水肿严重的病例,可在手术前立即给予类固醇药物或进行栓塞;3)患者在局部麻醉下接受该操作;4)尽可能将微导管插入靠近肿瘤的位置;5)颗粒栓塞剂是一线材料;6)偶尔使用氰基丙烯酸正丁酯(NBCA)胶进行栓塞;7)如有可能,使用弹簧圈对额外的近端供血动脉进行闭塞。JR-NET研究此前展示了日本颅内肿瘤栓塞的情况。血管内神经外科医生应与肿瘤神经外科医生充分讨论POE的适应症和策略,以确保操作安全有效。